Lymphocyte transformation and changes in leukocyte count: effects of anesthesia and operation.

Anesthesiology
B F Cullen, G van Belle

Abstract

The transformation of lymphocytes in response to phytohemagglutinin stimulation was investigated in 77 patients undergoind anesthesia with and without coincident surgical operation. A depression of lymphocyte transformation apparent immediately following major operations was related primarily to the extent of tissue trauma and not to the anesthetic agent or technique. No depression of lymphocyte transformation followed anesthesia for treatment of pain or for minor operations. The total leukocyte count increased following general anesthesia for prolonged, traumatic operations, primarily because of an influx of neutrophils into the circulation. The leukocyte count did not increase after comparable operations performed with regional anesthesia. Postoperative depression of lymphocyte transformation is primarily due to nonspecific stress, perhaps because of associated sympathetic and adrenocortical stimulation. The depressant effect of anesthesia alone is minimal.

Citations

Jan 1, 1977·Journal of Surgical Oncology·Y T Lee
Jan 1, 1978·Journal of Surgical Oncology·Y T LeeJ Jalaba
Jan 1, 1989·Intensive Care Medicine·W S Wren
Sep 1, 1997·Pediatric Surgery International·H W GrantT Doorasamy
Apr 1, 1996·Diseases of the Colon and Rectum·A EspíS Lledó
Sep 1, 1984·The Japanese Journal of Surgery·F MoriH Mohri
Jan 1, 1993·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Q LüZ Q Sun
Feb 24, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H IwasakaT Noguchi
May 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N Buckley
May 1, 1985·Injury·E FosseM Harboe
Mar 1, 1983·The Journal of Surgical Research·P KinnaertN Van Geertruyden
Sep 1, 1986·Veterinary Immunology and Immunopathology·P J FelsburgS I Rubin
Mar 1, 1986·Immunology Letters·M LerouxH Kirchner
Dec 1, 1983·Journal of Neuroimmunology·G RenouxD Degenne
Jan 1, 1987·International Journal of Immunopharmacology·J M NeubergerR Williams
Jul 1, 1985·Journal of Biological Standardization·V Jupa-MarcinkowskiP I Schmitz
Jun 28, 2000·Journal of Clinical Anesthesia·P Tassani
Mar 27, 2003·Journal of Clinical Anesthesia·Yoshiyuki HoriYoshifumi Tanaka
Sep 1, 1995·Anaesthesia·F A KhanM Khurshid
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·M Salo, J Eskola
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
Jul 1, 1992·Acta Anaesthesiologica Scandinavica·K MikawaH Obara
May 1, 1993·Acta Anaesthesiologica Scandinavica·E TønnesenP Toft
Aug 1, 1979·Archives of Disease in Childhood·P PuriE J Guiney
Jan 1, 1985·Scandinavian Journal of Thoracic and Cardiovascular Surgery·E FosseS Sunde
Jan 1, 1980·Scandinavian Journal of Thoracic and Cardiovascular Surgery·B SchildtK Rådegran
Jun 1, 1987·Journal of Cardiothoracic Anesthesia·R G PearlM H Rosenthal
Jun 24, 2004·Best Practice & Research. Clinical Anaesthesiology·Christine E SchneemilchUte Bank
Nov 1, 1985·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M L DruartF Contraine
Mar 1, 1977·The Journal of Surgical Research·J L TarpleyP B Chretien
Jun 1, 1983·Acta Anaesthesiologica Scandinavica·E TønnesenN Grunnet
Nov 1, 1986·Acta Anaesthesiologica Scandinavica·B W JakobsenB B Egeberg
Apr 1, 1987·Pharmacology & Toxicology·E LanghoffJ Ladefoged

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