Lymphocyte transformation in presumed ocular histoplasmosis

Archives of Ophthalmology
J P GanleyJ A Brody

Abstract

Lymphocytes from individuals with inactive macular disciform lesions of presumed ocular histoplasmosis challenged with three histoplasmin antigens incorporated tritiated thymidine at a significantly higher rate than histoplasmin-stimulated lymphocytes of matched control and peripheral scar groups. This finding is consistent with the etiologic association of the disciform ocular syndrome and previous systemic infection with Histoplasma capsulatum. The disciform group had a higher mean response than the other two groups to pokeweed mitogen but not to phytohemagglutinin and had higher mean counts per minute to the specific antigens Toxoplasma gondii, Blastomyces dermatitidis, Cryptococcus neoformans, Mycobacterium tuberculosis, M battery, and M gaus, but not to Candida albicans. These data would suggest that individuals with the disciform lesion of presumed ocular histoplasmosis have a hyperreactive cellular immune response; this response may play an important role in the development of the disciform.

Citations

Jun 1, 1996·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·F Q WenG L Baum
Jan 1, 1995·Documenta Ophthalmologica. Advances in Ophthalmology·J T DerosaR F Spaide
Feb 7, 2006·Optometry : Journal of the American Optometric Association·Richard Trevino, Ricardo Salvat
Nov 1, 1986·Australian and New Zealand Journal of Ophthalmology·W S Foulds, B E Damato

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