Lymphocytes, cytokines, inflammation, and immune trafficking

Current Opinion in Rheumatology
G C Tsokos

Abstract

Studies reported during the past year have added new knowledge to our understanding of cellular abnormalities in systemic lupus erythematosus: 1) Antigen-specific and "pathogenic" T cells display a limited T cell receptor repertoire in lupus. 2) The ratio of interleukin-10 to interferon gamma-secreting cells in the peripheral blood of patients with lupus is increased in patients with active disease. 3) CD3-mediated increases in free intracytoplasmic calcium occur specifically in lupus T cells and lines; this finding provides additional evidence that cell-signaling events are defective in patients with lupus. 4) Aberrant expression of adhesion molecules on the surface membrane of leukocytes and endothelial cells was shown, a finding with important mechanistic and therapeutic implications. 5) Lupus antigen-presenting cells fail to upregulate the expression of B7-1 (CD80) in response to interferon gamma; defective expression of B7-1 is responsible for the decreased response of lupus cells to recall antigens.

Citations

Jan 10, 2003·Clinical and Experimental Immunology·L Vieira de MoraesL V Rizzo
Aug 11, 2000·Seminars in Cancer Biology·C S Tannenbaum, T A Hamilton
Jan 16, 1999·Baillière's Clinical Rheumatology·L J Mason, D A Isenberg

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