PMID: 5910197Apr 22, 1966

Lymphocytes from thymectomized rats: immunologic, proliferative, and metabolic properties

Science
W O Rieke

Abstract

Thoracic duct lymphocytes from neonatally thymectomized Lewis rats fail to produce runt disease in newborn Brown Norway rats when injected with up to ten times the number of normal lymphocytes needed to cause runting. The immunologically deficient lymphocytes appear, however, to confer tolerance, and at least some enlarge and divide when stimulated in vitro with phytohemagglutinin, or xenogeneic or allogeneic cells. Small lymphocytes from thymectomized animals have defective RNA metabolism as judged by a marked impairment in their ability to incorporate uridine-5-H(3) or cytidine-H(3) in vitro.

Citations

Nov 1, 1967·The American Journal of Anatomy·M R Schwarz
Jan 1, 1968·The Anatomical Record·M R Schwarz
Jun 1, 1996·Veterinary Immunology and Immunopathology·E M BertramI Kotlarski
Aug 5, 1971·The New England Journal of Medicine·C G CraddockR McMillan
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Feb 1, 1968·The Journal of Pediatrics·H J MeuwissenR A Good
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Related Concepts

Natural Immunosuppression
Lymphoid Cells
Nucleosides
Nuclear Track Detection
RNA
Thymectomy
Tritium
Uridine
Animal Lectins

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