PMID: 7519007Jul 15, 1994Paper

Lymphocytes possess an electrogenic H(+)-transporting pathway in their plasma membrane

The Biochemical Journal
K KáldiE Ligeti

Abstract

The existence of an electrogenic H(+)-transporting pathway similar to that described in the plasma membrane of granulocytes and macrophages is reported in pig peripheral lymphocytes. The function of the H(+)-transport pathway can only be detected when free movement of charge-compensating cations is allowed. H+ transport is stimulated by arachidonic acid and various unsaturated fatty acids, and inhibited by bivalent cations, with the following sequence of efficiency: Zn2+ > Cd2+ = Co2+ = Ni2+ > Mn2+ > Ba2+ = Ca2+ = Mg2+. The transport pathway is activated by intracellular acidification and by NN'-dicyclohexylcarbodiimide, but it is not influenced by phorbol 12-myristate 13-acetate. As pig peripheral lymphocytes are not able to produce O2-., it is suggested that the operation of the electrogenic H+ conductance does not require the assembly of a functional NADPH oxidase.

Citations

Nov 16, 2002·The Journal of Physiology·Tom SchillingClaudia Eder
Jun 25, 2008·Seminars in Immunopathology·Balázs RadaErzsébet Ligeti
Jul 15, 2004·Blood·Balázs K RadaErzsébet Ligeti
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·K B Wallace, A A Starkov
Mar 29, 2003·Physiological Reviews·Thomas E Decoursey
Aug 15, 2001·American Journal of Physiology. Cell Physiology·L OliviJ Bressler
Feb 15, 1996·Biochimica Et Biophysica Acta·L M Henderson, J B Chappel

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