PMID: 6979608Jul 1, 1982Paper

Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections

The Journal of Experimental Medicine
C J PfauK D Hunt

Abstract

Two types of lymphocytic choriomeningitis (LCM) viruses were studied which, upon intracerebral injection into adult C3H mice, provoked either (a) acute fatal central nervous system (CNS) disease or (b) life-long persistent infection. Both virus types, (a) aggressive and (b) docile, had been found to induce LCM-specific lymphocytes with comparable in vitro lytic activity (11). Because the requirement for T cells in the development of adult LCM disease has been extensively documented, we sought other reasons for the lack of acute disease in mice infected with docile virus. A striking correlation was found between the outcome of the infection and spread of virus to visceral organs. Adoptive transfer experiments showed that a 300-plaque forming unit inoculum of docile virus induced a population of T cells in donor mice fully capable of causing CNS disease in identically infected recipients. This disease causing ability was lost if the interaction was delayed beyond 3 d after infection of the recipients, but could be preserved by lowering the size of the viral inoculum in the recipients. Furthermore, without adoptive transfer, very low intracerebral doses of docile virus (which mimicked the normally slow spread of aggressive virus) ...Continue Reading

References

Nov 1, 1973·The Journal of Experimental Medicine·R M Zinkernagel, P C Doherty
Jun 1, 1971·The Journal of Infectious Diseases·S Suzuki, J Hotchin
Dec 1, 1981·The Journal of General Virology·S JacobsonC J Pfau
Oct 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·W P ROWER H LEVEY

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Citations

Jan 1, 1986·Medical Microbiology and Immunology·R M ZinkernagelL Stitz
Aug 1, 1987·Immunology and Cell Biology·P C Doherty
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B OdermattR M Zinkernagel
Oct 3, 2009·Journal of Molecular Cell Biology·Dorian B McGavern
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R ThomsenJ P Christensen
Jun 1, 1993·Immunological Reviews·R M ZinkernagelH Hengartner
Dec 1, 1995·Immunological Reviews·M F van den BroekM Aguet
Mar 22, 2002·Journal of Virology·Weldy V BonillaHans Hengartner
Jan 1, 1996·Annual Review of Immunology·R M ZinkernagelH Hengartner
Jan 1, 1990·International Reviews of Immunology·D E Lewis, J V Giorgi
Apr 1, 1986·European Journal of Clinical Investigation·R M Zinkernagel
Aug 1, 1987·Scandinavian Journal of Immunology·S J WoodsC J Pfau
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C J PfauJ K Valenti
Apr 1, 1988·European Journal of Immunology·H RoostR M Zinkernagel
Dec 1, 1993·European Journal of Immunology·D MoskophidisR M Zinkernagel
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J P ChristensenA R Thomsen
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hans Christian ProbstMaries F van den Broek
Feb 23, 2019·Viruses·Tamara Suprunenko, Markus J Hofer

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