PMID: 11314750Apr 21, 2001Paper

Lymphocytic hypophysitis: report of an unusual case of a rare disorder

Journal of Endocrinological Investigation
M Durán MartínezS Monereo Megías

Abstract

A 36-year-old non-pregnant woman presented with a four-month history of progressive visual deterioration and amenorrhea. The latest gestation was 6 years earlier. Hormonal study revealed central diabetes insipidus, hypopituitarism, and slightly increased prolactin level. Ophthalmologic examination showed bilateral hemianopsia. In the magnetic resonance imaging an intrasellar mass with supra and retrosellar extension was found. The mass showed a polylobular aspect with heterogeneous signal within the tissue. The normal neurohypophysis could not be identified. Pterional craniotomy was performed. The pathological examinations revealed fibrous tissue with heavy inflammatory infiltrate composed of lymphocytes and plasma cells, islands of eosinophilic epithelial cells stained positively for chromogranin, GH, ACTH, and PRL and negatively for antibodies directed against HLA-II antigens. This case of lymphocytic hypophysitis was not related to pregnancy and involved the neurohypophysis. We discuss the features that can help to make a preoperative differential diagnosis.

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Citations

Mar 9, 2002·Journal of Endocrinological Investigation·P Iglesias, J J Díez
Jun 18, 2011·The American Journal of the Medical Sciences·Claudia Tonda, Ali A Rizvi
Oct 13, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hwa Jin ChoSung-Hye Park
May 25, 2013·Brain Pathology·Bette K Kleinschmidt-DeMasters, M Beatriz S Lopes
Jul 24, 2010·AJNR. American Journal of Neuroradiology·Y NakataK Ohtomo
Feb 25, 2009·The American Journal of Forensic Medicine and Pathology·Luis F Gonzalez-CuyarJoyce L Dejong
Jul 20, 2002·MCN. the American Journal of Maternal Child Nursing·Leslie Parker, Gene Cranston Anderson
Feb 1, 2017·Arkhiv patologii·L B MitrofanovaI V Antonova

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