PMID: 39565Oct 1, 1979

Lymphocytotoxic antibodies in systemic lupus erythematosus and clinically related diseases

Arthritis and Rheumatism
A L Schocket, P F Kohler


Sera from patients with systemic lupus erythematosus (SLE) and clinically related diseases were examined for cold-reactive lymphocytotoxic antibodies (LCA). The incidence of LCA was significantly increased in SLE (93%), discoid lupus (50%), and "lupus-like" syndromes associated with congenital complement deficiencies (63%) as compared to normal controls (3%) and patients with drug-induced lupus (11%), mixed connective tissue disease (MCTD) (17%), and necrotizing vasculitis (19%). The diagnostic and pathogenetic implications of these differences are discussed.


Nov 12, 1977·Lancet
Jan 1, 1978·The American Journal of Medicine·W J Fessel
Oct 1, 1978·The Journal of Allergy and Clinical Immunology·R G GowerR M McIntosh
Feb 1, 1976·Annals of Internal Medicine·J R MendiusR C Williams
Jul 1, 1976·Arthritis and Rheumatism·I MalavéZ Layrisse
Jun 1, 1975·The Journal of Clinical Investigation·R J DeHoratius, R P Messner
Dec 7, 1975·The New England Journal of Medicine·S J KorsmeyerR G Strickland
May 1, 1973·The Journal of Clinical Investigation·S W HuangR Hong
Oct 1, 1970·The New England Journal of Medicine·P I TERASAKIE V Barnett
Mar 28, 1970·Nature·K K MittalW T Butler
Nov 1, 1970·Transplantation·M J KreislerP I TERASAKI
Dec 5, 1964·Nature·C H VANGRAAN, C H WYNDHAM


Feb 1, 1981·Medizinische Monatsschrift für Pharmazeuten·G Cohnen
Jan 10, 2002·Annals of the Rheumatic Diseases·G E Eroglu, P F Kohler
Sep 1, 1980·The Journal of Clinical Investigation·N J DollJ E Salvaggio
Sep 1, 1982·The British Journal of Dermatology·A L SchocketD A Norris
Jan 1, 1981·Scandinavian Journal of Immunology·J JonssonR Norberg
Dec 1, 1983·Arthritis and Rheumatism·E Diaz-Jouanen, D Alarcon-Segovia
Oct 1, 1991·Clinical and Experimental Immunology·V TanejaA N Malaviya

Related Concepts

Lymphocyte Immune Globulin, Anti-Thymocyte Globulin (Equine)
Hemolytic Complement
Microcytotoxicity Test
Lupus Erythematosus, Discoid
Lupus Erythematosus, Systemic
Mixed Connective Tissue Disease
Polyarteritis Nodosa

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.