PMID: 45404Jul 1, 1979

Lymphocytotoxicity and immunosuppression by organotin compounds. Suppression of graft-versus-host reactivity, blast transformation, and E-rosette formation by di-n-butyltindichloride and di-n-octyltindichloride

Immunopharmacology
W SeinenH Hooykaas

Abstract

Di-n-butyltindichloride (DBTC) and di-n-octyltindichloride (DOTC) represent a new group of organometallic compounds with antilymphocytic properties. In rats they induce lymphocyte depletion in thymus and thymus-dependent areas of spleen and peripheral lymph nodes without signs of myelotoxicity or a generalized toxicity. The number and viability of cells isolated from thymus and peripheral lymphoid organs was severely decreased, whereas the number and viability of bone marrow cells was not reduced. Immunosuppressive properties of DBTC and DOTC are indicated, in this study, by a severe decrease of the graft-versus-host response and the response to the T-cell mitogens phytohemagglutinin and concanavalin A. The T-cell selectivity of these compounds is discussed. In vitro DBTC and DTOC are extremely cytotoxic. Blast transformation of human as well as rat thymocytes was already inhibited at concentrations as low as 0.02 micrograms DBTC (or 0.1 micrograms DOTC) ml medium. Also the E-rosette formation was inhibited at very low drug levels. The similarity of effects upon rat and human lymphocytes suggests that DBTC and DOTC acts in the same manner in rat and man and offers the possibility of a therapeutic use of these compounds.

References

Apr 1, 1995·International Journal of Immunopharmacology·R H PietersA H Penninks
Oct 1, 1981·The Veterinary Quarterly·J G Vos
Sep 1, 1984·The Veterinary Quarterly·A H Penninks, W Seinen
May 1, 1993·Food Additives and Contaminants·A H Penninks
Jan 1, 1988·Journal of Toxicology and Environmental Health·R J SmialowiczC B Copeland
May 22, 2007·Toxicology and Applied Pharmacology·Mélanie GrondinDiana A Averill-Bates
Jan 1, 1984·Clinical Immunology and Immunopathology·K MillerJ R Foster
Jan 9, 1998·Drug Metabolism Reviews·T J Benya
Jun 30, 2006·Toxicology Letters·P Sreedhar ReddyP Sreenivasula Reddy
Oct 30, 2008·Journal of Immunotoxicology·J G Vos
Dec 1, 1994·Human & Experimental Toxicology·R H PietersA H Penninks

Citations

Oct 1, 1969·Experimental Cell Research·H Blomgren, B Andersson
Jun 7, 1969·Nature·J F BachC Fournier

Related Concepts

Immune Response
T-Lymphocyte
Decreased Immunologic Activity [PE]
Spleen
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Drug Measurement
Neoplasm of Uncertain or Unknown Behavior of Thymus
Organometallic Compounds
Thymocyte
Disease of Thymus Gland

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