Lymphoepithelioma-Like Carcinoma in Liver

The American Journal of Pathology
Ismail LabgaaStephen C Ward

Abstract

Liver cancer, primarily encompassing hepatocellular carcinoma and intrahepatic cholangiocarcinoma, has become the second leading cause of worldwide cancer-related death during the past two decades. Lymphoepithelioma-like carcinomas (LELCs) are defined as tumors composed of undifferentiated epithelial cells with a prominent lymphoid infiltrate, and can arise in the liver as hepatocellular or cholangiocarcinoma forms. Patients with liver LELC display distinctive demographics and tumor characteristics. LELCs also appear to be associated with strikingly better outcomes compared to typical liver cancers, with 5-year survival rates of 57% to 100% versus 12% to 68%, respectively. Liver LELCs represent a unique model of immune response in liver cancer. Data on LELCs of the liver remain limited, and future comprehensive studies are needed to further elucidate this disease, which could ultimately offer precious insights for immunotherapeutic strategies in liver cancer.

Citations

Apr 1, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yutaka KurebayashiMichiie Sakamoto
Mar 26, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Luca FabrisMario Strazzabosco
Jun 7, 2019·The Journal of Pathology·Anthony W-H ChanNathalie Wong
Feb 23, 2019·European Radiology·Myeong-Jin KimChansik An
Sep 28, 2018·Case Reports in Pathology·Marcello FiloticoAlessandro D'Amuri
Mar 19, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Timothy KendallGuido Carpino
Jan 7, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Austin LinAnjana A Pillai
Jan 6, 2021·Clinical Journal of Gastroenterology·Asako NogamiHirotoshi Fujikawa
Nov 13, 2020·World Journal of Gastroenterology : WJG·Xiao-Hui QianWei-Lin Wang
Oct 6, 2020·Clinics in Liver Disease·Monika Vyas, Xuchen Zhang
Jun 14, 2019·Journal of Hepatology·Julien CalderaroJessica Zucman-Rossi
May 8, 2021·World Journal of Hepatology·Mukul Vij, Julien Calderaro
May 20, 2021·Journal of Clinical and Translational Hepatology·David J HermelDarren S Sigal
Jun 18, 2021·Indian Journal of Pathology & Microbiology·Monika Vyas, Dhanpat Jain
Aug 28, 2021·Cancers·Julius Maximilian KnerrMette Marie Rosenkilde
Nov 24, 2021·Journal of Gastrointestinal Cancer·Dina SweedImam Waked

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

© 2022 Meta ULC. All rights reserved