PMID: 12937190Aug 26, 2003Paper

Lymphohaematopoeitic cancer mortality among workers with benzene exposure

Occupational and Environmental Medicine
J J CollinsD Shepperly

Abstract

Lymphohaematopoeitic cancer mortality was examined among 4417 workers at a chemical plant by cumulative and peak benzene exposure. There was little evidence of increasing risk with increasing cumulative exposure for all leukaemias or acute non-lymphocytic leukaemias (ANL), or the other lymphohaematopoeitic cancers with the exception of multiple myeloma. For multiple myeloma, the SMRs were 1.1 (95% CI 0.3 to 2.5) in the non-exposed group, 1.4 (95% CI 0.2 to 5.1) in the <1 ppm-years, 1.5 (95% CI 0.2 to 5.4) in the 1-6 ppm-years, and 2.6 (95% CI 0.7 to 6.7) in the >6 ppm-years group. We found no trends by peak exposures for any of the cancers. However, when peak exposures over 100 ppm for 40 or more days were considered, the observed number of all leukaemias (SMR = 2.7, 95% CI 0.8 to 6.4), ANL (SMR = 4.1, 95% CI 0.5 to 14.9), and multiple myeloma (SMR = 4.0, 95% CI 0.8 to 11.7) were greater than expected. While the observed number of deaths is small in this study, the number of peak exposures greater than 100 ppm to benzene is a better predictor of risk than cumulative exposure. The dose rate of benzene and a threshold for exposure response may be important factors for evaluating lymphohaematopoietic risk.

References

Dec 1, 1979·Toxicology and Applied Pharmacology·R D IronsK A Muirhead
Jan 1, 1978·Archives of Environmental Health·M G OttR A Langner
Feb 1, 1976·Environmental Research·E C Vigliani, A Forni
Jan 1, 1990·Annals of the New York Academy of Sciences·B D Goldstein
Dec 1, 1989·British Journal of Industrial Medicine·G M Swaen, J M Meijers
Mar 1, 1988·American Journal of Epidemiology·H AustinP Cole
Jan 1, 1986·Journal of Chronic Diseases·H Austin, P Cole
Oct 1, 1986·British Journal of Industrial Medicine·G G BondR R Cook
Apr 23, 1987·The New England Journal of Medicine·R A RinskyP J Landrigan
Sep 1, 1983·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·S P TsaiR L Gibson
Feb 1, 1983·Environmental Research·P DecoufléA Blair
Jan 1, 1981·American Journal of Industrial Medicine·R A RinskyA B Smith
Jun 1, 1995·Occupational and Environmental Medicine·O Wong
Apr 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·M B PaxtonJ V Rodricks
Mar 1, 1996·American Journal of Industrial Medicine·P J Landrigan
Mar 1, 1996·American Journal of Industrial Medicine·S N YinW J Blot
Dec 1, 1996·Risk Analysis : an Official Publication of the Society for Risk Analysis·A R SchnatterM G Bird
May 1, 1997·Epidemiology·B IrelandS G Riordan

❮ Previous
Next ❯

Citations

Oct 14, 2004·Annals of Hematology·Antonia M S MüllerMonika Engelhardt
Feb 5, 2011·International Archives of Occupational and Environmental Health·Alberto ScarselliDavide Di Marzio
Jan 24, 2006·Archives of Environmental Health·Ami S PatelJoseph Schwerha
Mar 22, 2005·Occupational and Environmental Medicine·T SorahanR Doll
Jun 30, 2010·Environmental Health : a Global Access Science Source·Abdul KhaladeJouni J K Jaakkola
Jan 13, 2010·Environmental Health Perspectives·Jelle VlaanderenRoel Vermeulen
Dec 17, 2008·Environmental Health Perspectives·Jelle VlaanderenUNKNOWN ECNIS Integrated Risk Assessment Group, European Union Network Of Excellence
Jan 16, 2010·Cancer Epidemiology·Eleanor V Kane, Rob Newton
Aug 26, 2009·Regulatory Toxicology and Pharmacology : RTP·Giffe T JohnsonRaymond D Harbison
Nov 23, 2006·Annals of the New York Academy of Sciences·Peter F Infante
May 7, 2015·International Journal of Cancer. Journal International Du Cancer·Martha S LinetUNKNOWN Chinese Center for Disease Control and Prevention-U.S. National Cancer Institute Benzene Study Group
Oct 18, 2011·International Journal of Occupational Medicine and Environmental Health·Erik BobergDavid O Carpenter
Aug 24, 2011·Toxicology Mechanisms and Methods·David W PyattColleen A Cushing
Apr 2, 2011·Environmental Research·Evelyn O TalbottAngela M Malek
Apr 14, 2015·British Journal of Cancer·J S StenehjemT K Grimsrud
Feb 26, 2016·Occupational and Environmental Medicine·Francesca MatteiUNKNOWN ICARE Study Group
Feb 3, 2012·Human & Experimental Toxicology·D PengW Xiaomin
Jul 3, 2004·Epidemiology·Bernard Goldstein
May 12, 2005·Chemico-biological Interactions·S H LammD M Byrd
Nov 22, 2008·Toxicology and Industrial Health·S WilburO Faroon
Jan 25, 2018·International Journal of Environmental Research and Public Health·Tapani TuomiTiina Santonen
May 17, 2018·Occupational and Environmental Medicine·Hunter WardenVikki Ho
Dec 7, 2018·Journal of the National Cancer Institute·Martha S LinetUNKNOWN Chinese Center for Disease Control and Prevention–US National Cancer Institute Benzene Study Group
Feb 6, 2010·Journal of Occupational and Environmental Medicine·Dominik D Alexander, Meghan E Wagner
Apr 4, 2007·International Journal of Cancer. Journal International Du Cancer·Dominik D AlexanderDimitrios Trichopoulos
Mar 30, 2019·Risk Analysis : an Official Publication of the Society for Risk Analysis·Harvey CheckowayKenneth A Mundt
Jun 22, 2012·British Journal of Cancer·Terry BrownUNKNOWN British Occupational Cancer Burden Study Group
Mar 25, 2017·Molecular Medicine Reports·Chiara CostaConcettina Fenga
Jun 1, 2020·American Journal of Industrial Medicine·Martha S LinetNathaniel Rothman
Oct 14, 2010·Critical Reviews in Toxicology·David GalbraithDennis Paustenbach
May 20, 2011·Critical Reviews in Toxicology·Susan P FelterGary M Williams
Jul 3, 2004·Epidemiology·A Robert Schnatter
Oct 26, 2016·Molecular Medicine Reports·Luca FalzoneMassimo Libra
Jan 12, 2021·Toxicology Letters·Colin M NorthStephen D Williams
Jan 26, 2021·Frontiers in Public Health·M Abbas Virji, Laura Kurth
Jun 7, 2005·Chemico-biological Interactions·A Robert SchnatterNancy C Wojcik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.