Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors

The New England Journal of Medicine
A BakhshiS J Korsmeyer

Abstract

The origin and stage of differentiation of the blast-crisis cells in chronic myelogenous leukemia have remained uncertain. Because immunoglobulin heavy-chain and light-chain genes must undergo a DNA rearrangement during B-cell development but rarely do so in human non-B-cell lineages, we examined these genes in 18 episodes of chronic myelogenous leukemia. In eight of nine episodes of lymphoid blast crisis, heavy-chain genes were rearranged, and in three, rearrangements in light-chain genes were also present. In contrast, cells from chronic myeloid, myeloid blast, and erythroid-like phases retained germ-like immunoglobulin genes. The observed phenotypic markers and gene configurations revealed that most lymphoid blast crises represent stages of development of B-cell precursors. In two separate episodes of lymphoid crisis, cells from a single patient possessed identical heavy-chain but different light-chain-gene configurations. Thus, the precursor cells that monoclonally expand to produce a lymphoid crisis are capable of immunoglobulin-gene rearrangements and represent discrete steps in early B-cell maturation.

References

Jan 1, 1979·Immunological Reviews·F M BrodskyW F Bodmer
Nov 17, 1978·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J D Rowley
Jan 1, 1979·Methods in Enzymology·E Southern
Sep 1, 1977·Journal of the National Cancer Institute·T TsubotaD Pressman
Oct 1, 1978·The Journal of Clinical Investigation·P J FialkowM N Lowenthal
Jul 19, 1979·The New England Journal of Medicine·T W LeBienJ H Kersey
Feb 1, 1979·International Journal of Cancer. Journal International Du Cancer·L C AnderssonC G Gahmberg
Aug 9, 1973·The New England Journal of Medicine·R D Barr, P J Fialkow
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S J KorsmeyerT A Waldmann
Mar 1, 1983·The Journal of Experimental Medicine·J CossmanW C Greene
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S J KorsmeyerP Leder
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·J MinowadaT Ohnuma
May 14, 1981·The New England Journal of Medicine·H P Koeffler, D W Golde
Jan 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·E BEUTLERV F FAIRBANKS

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Citations

Nov 27, 1996·International Journal of Cancer. Journal International Du Cancer·E M WeissingerH J Kolb
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·T L Boehm, D Drahovsky
Jan 1, 1984·Journal of Clinical Immunology·S J Korsmeyer, T A Waldmann
Aug 1, 1987·Cancer Genetics and Cytogenetics·G Chenevix-TrenchU Francke
Sep 1, 1987·Cancer Genetics and Cytogenetics·H E AuerbachP C Nowell
Jun 1, 1995·Cancer Genetics and Cytogenetics·P RuffA Weaving
May 1, 1996·Critical Reviews in Oncology/hematology·J F San MiguelM A Sanz
Sep 24, 2010·Leukemia·I SlomaC J Eaves
Jan 13, 2012·Nature Reviews. Cancer·Long V NguyenConnie J Eaves
Oct 6, 1983·The New England Journal of Medicine·J H Kersey
Dec 29, 1983·The New England Journal of Medicine·A ArnoldS J Korsmeyer
Feb 2, 1984·The New England Journal of Medicine·J L Hamerton
Feb 23, 1984·The New England Journal of Medicine·R S Schwartz
Jul 5, 1984·The New England Journal of Medicine·J SklarR Levy
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A BakhshiS J Korsmeyer
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G F HollisJ P McKearn
Apr 1, 1985·The Journal of Experimental Medicine·E E Max, S J Korsmeyer
Aug 1, 1995·Journal of Hematotherapy·L M SillaE D Ball
Feb 8, 2006·Journal of Pediatric Hematology/oncology·Oussama AblaMohamed Abdelhaleem
Oct 1, 1991·British Journal of Haematology·E PaiettaP H Wiernik
Nov 1, 1991·British Journal of Haematology·J M HernándezA López-Borrasca
Jan 1, 1986·British Journal of Industrial Medicine·O WongL Kheifets
Nov 1, 1984·The Journal of Clinical Investigation·R FoaF Lauria
Mar 1, 1985·The Journal of Clinical Investigation·A A FauserG W Löhr
May 1, 1987·The Journal of Clinical Investigation·S J Korsmeyer

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