PMID: 9450800Feb 5, 1998Paper

'Lymphoid' blast crisis of chronic myeloid leukaemia is associated with distinct clinicohaematological features

British Journal of Haematology
F CervantesE Montserrat

Abstract

It has been suggested that in blast crisis (BC) of chronic myeloid leukaemia (CML) the clinical and laboratory features of patients with 'lymphoid' phenotype differ from those of patients with non-lymphoid BC. In order to assess any differences, 97 patients consecutively diagnosed with BC that followed a known chronic phase of CML were analysed. 19 patients had 'lymphoid' BC: in 17 the blasts expressed a B-lineage phenotype: in the remaining two they corresponded to T lymphoblasts. Four cases of B-lineage phenotype BC were considered as biphenotypic, due to the co-expression of myeloperoxidase and one or two other myeloid markers (CD33, CD13 and CD68) on the blast cells; in the other six cases of B-lineage BC the blasts expressed one or both of the myeloid markers CD33 (n = 4) and CD13 (n = 3). Patients with 'lymphoid' BC seldom had an accelerated phase prior to BC (1/19 v 36/78 with non-lymphoid BC, P = 0.002), had less frequent splenomegaly (9/19 v 59/78, P = 0.03) and hepatomegaly (5/19 v 45/78, P = 0.02) and showed a higher degree of marrow blast infiltration (mean value 74 +/- 24% v 38 +/- 23%, P < 0.0001), lesser blood basophilia (2.2 +/- 2.5% v 8.2 +/- 7.8%, P < 0.0001), and higher serum albumin levels (P = 0.001) than t...Continue Reading

References

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Citations

Apr 18, 2006·Current Treatment Options in Oncology·Merat Karbasian EsfahaniPeter H Wiernik
Mar 20, 2003·Experimental Hematology·Juan-Carlos Hernández-BoludaEmilio Montserrat
Mar 14, 2007·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·M GarziaG Zini
Oct 27, 2015·Clinical Lymphoma, Myeloma & Leukemia·Fernando Pérez-JacoboXavier López-Karpovitch
Oct 17, 2003·Hematology/oncology Clinics of North America·Tracy I George, Daniel A Arber
Jul 25, 2003·Cancer·Guillermo Garcia-ManeroHagop M Kantarjian
Aug 24, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·J ThieleH E Schaefer
Jul 16, 2005·Leukemia & Lymphoma·Juan-Carlos Hernández-BoludaFrancisco Cervantes
Jul 9, 1999·American Journal of Hematology·G A Martín-HenaoJ García
Jul 10, 1999·Current Opinion in Hematology·U R Osarogiagbon, P B McGlave
May 15, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frédéric MillotMeinolf Suttorp
Apr 24, 2003·Archives of Pathology & Laboratory Medicine·Socorro M Rodríguez-PinillaP Martinez Sanchez

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