PMID: 8969070Nov 1, 1996Paper

Lymphoid follicle formation in sinus mucosa of chronic sinusitis

Nihon Jibiinkoka Gakkai kaiho
H Tsurumaru

Abstract

While the presence of mucosa-associated lymphoid tissue (MALT) in the human upper respiratory mucosa is still being debated, it is known that lymphoid follicles (LFs) are present in the mucosa of patients with chronic sinusitis. In the present study, we investigated LFs in chronic sinusitis mucosa samples for the first time immunohistochemically to reveal the frequency and process of lymphoid follicle formation. Forty maxillary sinus mucosa samples from 27 surgical cases were examined. Of the 31 samples, 15 (48.4%) contained primary and/or secondary LFs, 27 (87.1%) contained lymphocyte aggregates (LAs), and 27 (87.1%) contained high endothelial venules (HEVs) located in the LAs and around the LFs. In the inflammatory site above the lesion of the LAs or LFs, respectively, intraepithelial lymphocyte infiltration and a non-ciliated structure or lympho epithelium were seen. In the first phase of diffuse lymphocyte infiltration, CD8+ T cells (suppressor/cytotoxic) were the predominant cells observed in a spreading pattern under the epithelium. In the next phase, while OPD4+ T cells (helper/inducer) were infiltrating, L26+ B cells were gradually aggregating to form lymphocyte clusters (LCs). S-100+ antigen-presenting cells and DRC+ f...Continue Reading

Citations

Oct 23, 2002·The Annals of Otology, Rhinology, and Laryngology·Shin-ichi HaginomoriIsamu Sando
May 24, 2000·The Annals of Otology, Rhinology, and Laryngology·M KamimuraC Suzuki
Apr 10, 2010·Journal of Applied Oral Science : Revista FOB·José Luiz Santos Parizi, Gisele Alborghetti Nai

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