PMID: 6966820Jan 1, 1980Paper

Lymphoid stem cells in the intraembryonic mesenchyme of the chicken

Scandinavian Journal of Immunology
O LassilaF Dieterlen-Lièvre

Abstract

Chromosomally marked cells from the 7-day intraembryonic mesenchyme were transplanted into 14-day-old irradiated chick embryos. At the age of 6 weeks donor-derived T and B lymphocytes were shown to be present in the thymus, spleen and bone marrow, indicating that cells in the 7-day intraembryonic mesenchyme are capable of developing into functional T and B lymphocytes. In addition to the sex chromosome marker, IgG allotype was used as a marker; the results demonstrate that cells from intraembryonic haemopoietic sites develop into mature IgG-producing cells. In similar experiments, the 7-day yolk sac also proved to contain lymphoid stem cells. Since lymphoid cell progenitors are not present in the 2-day yolk sac, as has been shown previously in the yolk sac-embryo chimaeras and since circulation is established from day 2 of incubation onwards, lymphoid stem cells present in the 7-day yolk sac are most likely secondary immigrants originating in the intraembryonic mesenchyme.

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Citations

Nov 1, 1981·Developmental Biology·F Dieterlen-Lièvre, C Martin
Apr 1, 1992·Current Opinion in Immunology·J C Weill, C A Reynaud
Feb 26, 2000·Developmental and Comparative Immunology·C Siatskas, R Boyd
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C WeillJ R Pink
Jan 5, 2007·Annual Review of Immunology·Ana Cumano, Isabelle Godin
Jul 1, 1984·The American Journal of Anatomy·N M Le DouarinP D Oliver
Feb 17, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Karine BollerotThierry Jaffredo
Jul 6, 2014·Experimental Hematology·Thierry Jaffredo, Laurent Yvernogeau
Jan 27, 1998·Hematology/oncology Clinics of North America·F Dieterlen-Lièvre
Aug 6, 2000·Developmental Biology·T JaffredoF Dieterlen-Lièvre
Sep 11, 2004·Mechanisms of Development·Françoise Dieterlen-Lièvre, Nicole M Le Douarin
Jan 1, 1981·Developmental and Comparative Immunology·O Lassila
May 21, 2017·Development·Laurent Yvernogeau, Catherine Robin
Sep 1, 1982·Scandinavian Journal of Immunology·O LassilaP Toivanen

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