Lymphoid tissue fibrosis is associated with impaired vaccine responses

The Journal of Clinical Investigation
Cissy KityoTimothy W Schacker

Abstract

Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection. We found blunted antibody responses to YFV that correlated to the amount of LN fibrosis and loss of T cells, including T follicular helper cells. These data suggest that LN fibrosis is not limited to HIV infection and may be associated with impaired immunologic responses to vaccines. This may have an impact on vaccine development, especially for infectious diseases prevalent in the developing world.

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May 22, 2018·The Journal of Clinical Investigation·Boris Julg, Galit Alter
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Methods Mentioned

BETA
biopsies
biopsy
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT00254826

Software Mentioned

R
BitPlane
Aperio ImageScope
gee
Imaris
Adobe Photoshop
xtable
Reindeer Graphics
beeswarm

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