PMID: 7519197Apr 1, 1994Paper

Lymphoid tissue in the endometrium of women with unexplained infertility: morphometric and immunohistochemical aspects

Human Reproduction
L D KlentzerisI D Cooke

Abstract

The purpose of this study was to investigate whether the endometrium of women with unexplained infertility differs in some immunological aspects from the endometrium of normal fertile women. Endometrial biopsies were obtained from 24 normal fertile women (group I) and 24 women suffering from unexplained infertility (group II) at 4, 7, 10 and 13 days following the luteinizing hormone (LH) surge. Endometrial granulated lymphocytes were assessed morphometrically in 2 microns resin sections. A panel of 11 monoclonal antibodies was employed to characterize the leukocyte subsets in frozen sections. Semi-quantification was performed with a Quantimet 970 image analyser. Data were analysed using one- and two-way analysis of variance. Compared with fertile controls, women with unexplained infertility had significantly lower numbers of CD8+ (T suppressor/cytotoxic) cells at each post-LH date. In contrast, the number of CD4+ (T helper/inducer) cells was significantly higher in group II. Throughout the luteal phase, infertile women had fewer CD56+ cells than normal fertile controls. The volume fraction of endometrium occupied by the nuclei of endometrial granulated lymphocytes did not alter with the cycle stage but the mean nuclear diameter...Continue Reading

Citations

Feb 12, 1998·American Journal of Reproductive Immunology : AJRI·A M Stewart-AkersJ A DeLoia
Jul 11, 2006·Biology of Reproduction·Paula J ScaifeRoger F Searle
Apr 25, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M R RaspolliniG L Taddei
Feb 27, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marina I KrivonosKhadizhat Sultangadzhieva
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Jan 23, 2021·Genomics, Proteomics & Bioinformatics·Feiyang WangYan-Ling Wang
May 8, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Steve Genebrier, Karin Tarte
Jan 13, 2019·Science Immunology·Stephanie E AnderCarolyn B Coyne

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