Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses

Seminars in Immunology
Peter J L LaneGraham Anderson

Abstract

Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells.

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Citations

Dec 17, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Harinder MankuTimothy J Vyse
Mar 27, 2012·Seminars in Immunology·Hsin-Ying Huang, Sanjiv A Luther
Aug 8, 2009·Clinical and Experimental Immunology·M-Y KimP Lane
Jan 5, 2011·Immunity·Gregory F SonnenbergDavid Artis
Nov 16, 2010·Cytokine & Growth Factor Reviews·Joseph M ReynoldsChen Dong
Jun 19, 2010·Nature Reviews. Immunology·Daniel J Cua, Cristina M Tato

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