Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?

Frontiers in Immunology
Peter J L LaneGraham Anderson

Abstract

PHYLOGENY SUGGESTS THAT THE EVOLUTION OF PLACENTATION IN MAMMALS WAS ACCOMPANIED BY SUBSTANTIAL CHANGES IN THE MAMMALIAN IMMUNE SYSTEM: in particular lymph nodes and CD4 high affinity memory antibody responses co-evolved during the same period. Lymphoid tissue inducer cells (LTi) are members of an emerging family of innate lymphoid cells (ILCs) that are crucial for lymph node development, but our studies have indicated that they also play a pivotal role in the long-term maintenance of memory CD4 T cells in adult mammals through their expression of the tumor necrosis family members, OX40- and CD30-ligands. Additionally, our studies have shown that these two molecules are also key operators in CD4 effector function, as their absence obviates the need for the FoxP3 dependent regulatory T (T(regs)) cells that prevent CD4 driven autoimmune responses. In this perspective article, we summarize findings from our group over the last 10 years, and focus specifically on the role of LTi in thymus. We suggest that like memory CD4 T cells, LTi also play a role in the selection and maintenance of the T(regs) that under normal circumstances are absolutely required to regulate CD4 effector cells.

Citations

May 28, 2014·The Journal of Experimental Medicine·Meryem JarjourMarc Bajénoff
Oct 18, 2014·Nature Reviews. Immunology·Taku Kambayashi, Terri M Laufer
Apr 20, 2014·Frontiers in Immunology·Monica KilligChiara Romagnani
Jan 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor H EngelhardCraig L Slingluff
Oct 9, 2018·Immunological Reviews·Nora BranzkAndreas Diefenbach
Jan 8, 2013·Nature Reviews. Immunology·Jennifer A WalkerAndrew N J McKenzie
Nov 18, 2018·Science Immunology·Pedro P HernándezAna Cvejic
Nov 25, 2016·Journal of Immunology Research·Fabian Flores-BorjaTony Ng
Apr 15, 2021·Biomedical Journal·Serge A van de Pavert

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