Lymphoid tissue ontogeny in the mummichog, Fundulus heteroclitus.

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Laura R Hunt, Charles D Rice

Abstract

Most studies that examine the ontogeny of lymphoid organ development in teleostean fishes use species of interest to aquaculture or genetic research and, to date, have focused strictly on marine or freshwater species. The mummichog, Fundulus heteroclitus, also known as the estuarine killifish, is a unique model for studies on developmental immunobiology, because it is euryhaline, has a high degree of thermal tolerance, and has a unique reproductive strategy. Embryonic and larval mummichogs were examined for the ontogeny of lymphoid tissue development. The first lymphoid organ to appear was the head kidney at 1 dph, followed by the spleen at 1 wph, and then the thymus at 3 wph. Rag-1 was partially cloned and sequenced and shown to be highly conserved among other vertebrate Rag-1 genes. Using QT-PCR to monitor the temporal expression of Rag-1, it was shown to reach a maximum intensity at 3 and 4 wph and then to drop to pre-2-wph levels. Overall, this study suggests that juvenile mummichogs do not possess the ability to mount T- or B-cell responses until some time after 5 wph. Even though the estuarine killifish tolerates a wide range of salinities, the developmental patterns of lymphoid tissues are similar to what has been report...Continue Reading

References

Jul 1, 1978·Developmental and Comparative Immunology·J B Solomom
Mar 6, 1992·Cell·P MombaertsV E Papaioannou
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Reichman-FriedM J Bosma
Dec 11, 1993·Nucleic Acids Research·M J SadofskyM Gellert
Feb 15, 1997·Developmental Biology·C E WillettL A Steiner
Jan 7, 1999·Developmental and Comparative Immunology·M B SchrøderT O Jørgensen
Aug 11, 2001·Veterinary Immunology and Immunopathology·L Petrie-Hanson, A J Ainsworth
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nadia Danilova, Lisa A Steiner
Jun 26, 2003·Nucleic Acids Research·Ramu ChennaJulie D Thompson
Sep 13, 2003·Immunological Reviews·Thomas BoehmMichael Schorpp
Apr 15, 2004·Immunology Letters·Louis Du Pasquier
May 27, 2004·European Journal of Immunology·Ching-Yu Huang, Osami Kanagawa
May 14, 2005·Fish & Shellfish Immunology·I B Falk-Petersen
Jun 9, 2005·Fish & Shellfish Immunology·A ZapataA Cortés
Jun 22, 2005·Developmental and Comparative Immunology·Heidi B T HuttenhuisJan H W M Rombout
Sep 9, 2006·Human Mutation·Cristina SobacchiAnna Villa
Nov 1, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Sarandeep S HujaYan Li
Nov 1, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Chandrashekhar CharavaryamathBaljit Singh
Jun 1, 1994·The Biological Bulletin·S HsiaoR A Wallace

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Citations

Dec 12, 2020·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Larissa KernenChristyn Bailey
May 16, 2009·Fish & Shellfish Immunology·P Swain, S K Nayak

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