Lymphokine-activated killer cells in primary immunodeficiencies and acquired immunodeficiency syndrome

Clinical Immunology and Immunopathology
T W ChinE R Stiehm

Abstract

Cytotoxic mechanisms (e.g., natural killer (NK) lysis, antibody-dependent cellular cytotoxicity, and cytotoxic T lymphocyte lysis) play an important role in host defense against various infections and neoplasms. Lymphokine-activated killer (LAK) cytotoxicity, induced in vitro by incubating mononuclear cells with interleukin 2 (IL-2) for 2-5 days, may also represent an important component of the body's cytotoxic repertoire. In 10 patients with congenital cellular immunodeficiencies, including 5 with severe combined immunodeficiency, the mean LAK activity in a 3-hr chromium release assay against Raji target cells was 44 +/- 8.1%, which is equivalent to that observed in normal adults and neonates. In only one case, a patient with reticular dysgenesis, was there absent LAK cell generation. Haploidentical T cell-depleted bone marrow transplantation (BMT) restored LAK activity in this patient. LAK activity was first observed in this patient and two others 3-6 weeks following BMT, prior to other evidence of immunologic engraftment such as lymphocyte proliferation to mitogens, NK activity, or interferon-gamma production. One patient with adenosine deaminase deficiency showed normal levels of LAK activity despite absent NK activity. Thr...Continue Reading

References

Jun 1, 1986·Clinical Immunology and Immunopathology·C MessinaC Lopez
Feb 1, 1986·Cellular Immunology·A GoldsobelE R Stiehm
Jul 1, 1983·Pediatric Research·H S WinterE R Stiehm
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T W ChangJ Le

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Citations

Feb 19, 2005·Critical Reviews in Oncology/hematology·Eiichi IshiiMasaki Yasukawa
Sep 1, 1992·Clinical and Experimental Immunology·C GryllisB G Brenner
Aug 1, 1993·Clinical and Experimental Immunology·B G BrennerM A Wainberg

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