Lymphokine-augmented activation of avian heterophils

Poultry Science
Michael H KogutJ R DeLoach

Abstract

Heterophils are important mediators of innate resistance in poultry, especially in young birds that have not yet developed an acquired immune response. Invasion of the intestinal mucosa by Salmonella spp. initiates the recruitment of large numbers of heterophils to the lamina propria. Thus, the heterophilic response can control, but not eliminate, bacterial numbers in the bird until development of acquired immunity. Unfortunately, chicks and turkey poults are highly susceptible to Salmonella infections during the first 4 d posthatch due to the functional immaturity of both the innate and acquired immune systems. We have previously shown that the administration of Salmonella enteritidis (SE)-immune lymphokines (ILK) into either 18-d-old developing embryos or day-of-hatch chicks and poults conferred increased resistance to SE organ invasion. In this review, we present evidence that the protection induced by ILK is mediated by vigorous recruitment and activation of heterophils. These activated heterophils migrate rapidly to the site of bacterial invasion where they phagocytize and kill the SE. Specifically, in vitro studies demonstrate an enhancement of functional activities of the heterophils including chemotaxis, adherence, phag...Continue Reading

Citations

Jul 5, 2011·Polish Journal of Veterinary Sciences·M SmiałekA Koncicki
Jun 8, 2011·Veterinary Immunology and Immunopathology·Phongsakorn ChuammitriDušan Palić
May 18, 2016·Veterinary Immunology and Immunopathology·Martina HesseAngela Berndt
Apr 16, 2013·Developmental and Comparative Immunology·Kenneth J GenoveseMichael H Kogut
Jul 16, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael H KogutPete Kaiser
May 8, 2009·The Journal of Veterinary Medical Science·Takaaki AndoDaisaku Watanabe
Jan 18, 2005·Memórias do Instituto Oswaldo Cruz·Ana C V M da RochaPaulo F P Pimenta
May 16, 2003·Journal of Food Protection·Tawni L CrippenMichael H Kogut
Dec 14, 2017·Veterinary Sciences·K Denise AppersonChristiane V Löhr
Dec 21, 2011·Poultry Science·H Al-KhalifaP Yaqoob

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