PMID: 2494899Mar 1, 1989Paper

Lymphokine production by blood or spleen mononuclear cells from patients with schistosomiasis mansoni

The American Journal of Tropical Medicine and Hygiene
T M DabesF J Ramalho-Pinto

Abstract

Peripheral blood mononuclear cells (PBMN) from individuals with active or former intestinal schistosomiasis mansoni or splenocytes from patients with the hepatosplenic form of the disease were evaluated for their ability to generate chemotactic factors for neutrophils in response to schistosomal antigenic preparations derived from adult worms (SWAP), eggs (SEA), or phytohemagglutinin (PHA). When supernatants from cultures of stimulated PBMN from normal donors were assayed, only those obtained from cells which had been cultured in presence of PHA displayed chemotactic activity for neutrophils. In contrast, supernatants from cultures of SWAP or SEA stimulated PBMN from patients with intestinal or hepatosplenic schistosomiasis were shown to contain chemotactic activity for neutrophils from normal individuals. PBMN from persons who previously had been infected with Schistosoma mansoni but had received chemotherapy years before presented a pattern of response to SWAP or SEA similar to those from patients with active infections. The response of splenocytes from patients with hepatosplenic schistosomiasis was considerably different from PBMN from individuals with active or with treated schistosomiasis. Splenocytes from most of those p...Continue Reading

Citations

Aug 20, 2010·Memórias do Instituto Oswaldo Cruz·Denise Silveira-LemosRodrigo Corrêa-Oliveira
Apr 1, 1992·Revista Da Sociedade Brasileira De Medicina Tropical·G Gazzinelli, D G Colley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Canavan Disease

Canavan disease, a type of leukodystrophy, is an autosomal recessive neurodegenerative disorder, and is one of the most common degenerative cerebral diseases of infancy. Discover the latest research on Canavan disease here.