PMID: 6169650Jan 1, 1981Paper

Lymphokine production by PHA-stimulated human lymphocytes is enhanced by interferon

International Archives of Allergy and Applied Immunology
H Blomgren, S Einhorn

Abstract

Human interferon (IFN) was examined for its capacity to modify the phytohaemagglutinin (PHA)-triggered release of mitogenic factors (MF) from human lymphocytes in vitro. It was observed that the presence of partially purified leukocyte IFN (IFN-alpha) during the PHA pulsing of lymphocytes increased their subsequent release of factors which were mitogenic for fractionated T cells. A similar effect was also observed when lymphocytes were exposed to IFN-alpha prior to PHA pulsing. The possibility that substances in the IFN preparations other than IFN are responsible for the above effect is ruled out by the finding that a pure fibroblast IFN (IFN-beta) preparation also augmented the MF release by PHA-pulsed lymphocytes.

Citations

Oct 1, 1985·Veterinary Immunology and Immunopathology·N Craven, M R Williams
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I J RussellA B Richards
Aug 1, 1990·American Journal of Reproductive Immunology : AJRI·E NikolovaI Goranov
Jun 1, 1986·Australian and New Zealand Journal of Medicine·P Hersey
Oct 1, 1986·Journal of Interferon Research·I RosztóczyI Béládi
Jul 1, 1986·European Journal of Immunology·F J Dumont, L Z Coker
Jan 1, 1993·Medical Oncology and Tumor Pharmacotherapy·S Einhorn, H Strander

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