Lymphoma and leukemia cells possess fractal dimensions that correlate with their biological features

Acta Haematologica
Adi MashiahMeir Lahav

Abstract

Living cells can be viewed as complex adaptive systems that exhibit non-linear dynamics and fractal features. We investigated the fractal qualities of normal and malignant hematological cells and their potential as a tool for characterizing cell phenotype and clinical behavior. A mathematical algorithm and an optic tool for fractal analysis of nuclei were developed. A total of 4,713 lymphoid cells derived from 66 patients of five distinct diagnostic groups (normal and reactive lymphocytes, low-grade lymphomas and an aggressive lymphoma) were assessed for their fractal dimension. In addition, in 19 patients fractal analysis of leukemia cells was compared to clinical endpoints. After validating our method, hematological cells possessed fractal dimensions corresponding to their clinical entity. There was a highly significant overall difference in fractal dimensions between various types of hematological malignancies. A preliminary correlation was found between the fractal dimension and the clinical outcome of leukemia patients. Hematological cells possess fractal dimensions that correlate with their biological properties. Measurement of fractal dimension seems to be a sensitive method to assess the hematological cell phenotype and...Continue Reading

Citations

Nov 30, 2011·Epigenomics·Konradin Metze
Jul 22, 2011·Journal of Liposome Research·Natassa PippaEmmanuel Danezis
Sep 26, 2013·Expert Review of Molecular Diagnostics·Konradin Metze
Oct 16, 2015·Future Oncology·Igor Sokolov
Nov 15, 2013·Platelets·Max-Joseph KrausErwin F Strasser
Jul 6, 2012·Journal of Theoretical Biology·Igor PanticVladimir Trajkovic
Oct 11, 2014·PloS One·Markus FabriziiHelmut Ahammer
Jan 18, 2018·Physiological Measurement·Wlodzimierz KlonowskiRyszard Gomolka
Jan 13, 2018·International Journal of Surgical Pathology·Evan HimchakYanhua Wang
Apr 23, 2019·Expert Review of Molecular Diagnostics·Konradin MetzeJoão Batista Florindo
Sep 12, 2012·Journal of Computational Chemistry·Ilia A Solov'yovAndrey V Solov'yov
Mar 20, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Pengchao Zhang, Shutao Wang
Jun 27, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Marko DinčićAndjelija Ž Ilić
Sep 30, 2017·Frontiers in Oncology·Elizabeth A W Sigston, Bryan R G Williams
Apr 3, 2020·Medical & Biological Engineering & Computing·Zahra Sadat Hosseini, Seyed Mohammad Reza Hashemi Golpayegani
Oct 14, 2021·European Biophysics Journal : EBJ·Marko DinčićAndjelija Ž Ilić
Nov 2, 2021·PeerJ. Computer Science·Si Thu Aung, Yodchanan Wongsawat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.