Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection.

Journal of Virology
Katja C ErlachJürgen Podlech

Abstract

Cytomegalovirus (CMV) poses a threat to the therapy of hematopoietic malignancies by hematopoietic stem cell transplantation, but efficient reconstitution of antiviral immunity prevents CMV organ disease. Tumor relapse originating from a minimal residual leukemia poses another threat. Although a combination of risk factors was supposed to enhance the incidence and severity of transplantation-associated disease, a murine model of a liver-adapted B-cell lymphoma has previously shown a survival benefit and tumor growth inhibition by nonlethal subcutaneous infection with murine CMV. Here we have investigated the underlying antitumoral mechanism. Virus replication proved to be required, since inactivated virions or the highly attenuated enhancerless mutant mCMV-DeltaMIEenh did not impact the lymphoma in the liver. Surprisingly, the dissemination-deficient mutant mCMV-DeltaM36 inhibited tumor growth, even though this virus fails to infect the liver. On the other hand, various strains of herpes simplex viruses consistently failed to control the lymphoma, even though they infect the liver. A quantitative analysis of the tumor growth kinetics identified a transient tumor remission by apoptosis as the antitumoral effector mechanism. Tumo...Continue Reading

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Citations

Mar 18, 2008·Medical Microbiology and Immunology·Rafaela HoltappelsMatthias J Reddehase
Mar 31, 2015·Leukemia & Lymphoma·Michael KoldehoffAhmet H Elmaagacli
Mar 27, 2007·Cancer Letters·Markus J V Vähä-KoskelaAri E Hinkkanen
Sep 15, 2016·Molecular Therapy Oncolytics·Amit KumarGeorges Herbein
Oct 14, 2016·Leukemia & Lymphoma·Jonathan U Peled, Robert R Jenq
Apr 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole A WilskiChristopher M Snyder
Mar 7, 2020·Molecular Therapy Oncolytics·Layal MassaraMyriam Capone
Apr 18, 2020·Molecular Therapy Oncolytics·Georges Herbein, Zeina Nehme

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