PMID: 6980614Aug 1, 1982Paper

Lymphoma with autoimmune neutropenia and hepatic sinusoidal infiltration: a syndrome

Annals of Internal Medicine
M S KruskallS H Robinson

Abstract

A relation between lymphoma and autoimmune neutropenia, unlike autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura, has not previously been well documented. We report a patient with a disorder presenting as autoimmune agranulocytosis, splenomegaly, and infiltration of the hepatic sinusoids by lymphocytes. Antineutrophil antibodies were present. Over a 2 1/2-year period, the illness progressed to an aggressive, poorly differentiated lymphocytic lymphoma with terminal liver failure and fibrosis. Peripheral blood lymphocyte markers identified the tumor as a proliferation of T-cells of the helper class. A review of previous literature disclosed other reports of similar patients who had neutropenia, a lymphoproliferative illness, and hepatic disease. Our case is representative of a previously unrecognized syndrome characterized by autoimmune neutropenia in the setting of a lymphoproliferative disorder of T cells, with a predilection for liver involvement.

Citations

Jan 1, 1989·Clinical and Laboratory Haematology·P A CarringtonJ B Houghton
Apr 1, 1989·Baillière's Clinical Gastroenterology·L M Blendis
Sep 8, 2001·The American Journal of Medicine·L GarderetA Najman
Aug 1, 1986·British Journal of Haematology·J F ChapmanA H Waters
Aug 1, 1987·British Journal of Haematology·P K RustagiG L Logue
Apr 1, 1986·Pathology·B J RowbothamR J Collins
Aug 6, 2000·Medical Hypotheses·Y Bar-DayanY Shoenfeld
Dec 13, 2006·Travel Medicine and Infectious Disease·Ranjan K Singh
May 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M L RoquetY Pinaudeau
Sep 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P GaulardY Pinaudeau

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