PMID: 2490877Jun 1, 1989Paper

Lymphomatoid granulomatosis vs. leprosy

Hansenologia Internationalis
S J AdadA Nunes

Abstract

Lymphomatoid granulomatosis (LYG) was first described by LIEBOW, A.A. et al. Histologically is characterized by an lymphohistiocytic infiltrate with granulomatous features, polymorphous and pleiomorphic, angiocentric and angiodestructive and mainly involves lungs, skin, kidneys and CNS. LYG does not involves spleen, bone marrow and lymph nodes. Presently there is a concept that LYG is an angiocentric variant of T-cell peripheral lymphoma and histologically indistinguishable from polymorphic reticulosis of the upper airways (midline lethal granuloma). The prognosis for patients with LYG is guarded. Treatment with cyclophosphamide and prednisone may lead to remission in early cases. The skin is the most commonly involved extrapulmonary organ and in 13 to 34% of patients the skin lesions precede the pulmonary involvement. The clinical features of the skin lesions may vary, but frequently they are erythematous and violaceous plaque lesions or annular infiltrated lesions with central clearing. The differential diagnosis of these lesions includes granuloma annular, sarcoidosis and Hansen's disease. Since Hansen's disease is common among us and that LYG includes involvement of cutaneous branches and nerve trunks, with hypo or hyperest...Continue Reading

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