PMID: 8987063Nov 1, 1996Paper

Lymphomatoid papulosis: successful weekly pulse superpotent topical corticosteroid therapy in three pediatric patients

Pediatric Dermatology
M A PaulJ L Jorizzo

Abstract

Lymphomatoid papulosis is a T-cell proliferation that occurs primarily in adults but has been well described in children. Lesions may regress spontaneously but often leave residual scarring and, as a result, intervention frequently is considered. Therapeutic modalities commonly employed for adults with lymphomatoid papulosis may be poorly tolerated by pediatric patients. We present a series of three children with lymphomatoid papulosis treated with superpotent topical corticosteroids (halobetasol or clobetasol propionate). When applied twice daily for 2 to 3 weeks followed by weekly pulsed application, this treatment resulted in complete resolution of nearly all cutaneous lesions. Three ulcerated lesions, occurring in two patients, required adjuvant therapy with intralesional triamcinolone. To date one patient remains free of cutaneous disease and two children experience occasional new lesions that respond to renewed treatment with topical clobetasol propionate. None of the children have evidence of systemic disease. We conclude that pulsed application of a superpotent topical corticosteroid is efficacious and safe in the management of cutaneous lesions of lymphomatoid papulosis and avoids the risks often associated with more a...Continue Reading

References

Oct 1, 1992·Journal of the American Academy of Dermatology·M A BarnadasJ M de Moragas
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S J ProctorJ Marks
Mar 1, 1991·Pediatric Dermatology·A PatriziB Passarini
Oct 1, 1987·Journal of the American Academy of Dermatology·K Thomsen, G L Wantzin
Nov 1, 1987·Pediatric Dermatology·J AshworthR M MacKie
Jul 1, 1986·Southern Medical Journal·J W Patterson, R M White
Jan 1, 1987·Journal français d'ophtalmologie·J M LemagneP Maldague
Jun 1, 1985·Archives of Dermatology·G L WantzinJ K Larsen
Nov 1, 1985·Archives of Dermatology·H S ZackheimW R Crain
Oct 1, 1984·Pediatric Dermatology·M RogersA Bishop
Jul 1, 1984·The British Journal of Dermatology·G Lange Wantzin, K Thomsen
Jan 1, 1983·Journal of the American Academy of Dermatology·N P SanchezR K Winkelmann
Apr 1, 1981·Journal of the American Academy of Dermatology·S R ScheenR K Winkelmann
Aug 1, 1982·The British Journal of Dermatology·R WillemzeE Scheffer
Dec 1, 1982·The British Journal of Dermatology·G L Wantzin, K Thomsen
Jan 1, 1981·The American Journal of Dermatopathology·V F Weinman, A B Ackerman
Jun 24, 1995·La Presse médicale·B Dreno
Nov 1, 1995·Journal of the American Academy of Dermatology·G M ZirbelN B Esterly
Mar 1, 1994·Journal of the American Academy of Dermatology·D L Karp, T D Horn
Jun 1, 1994·Journal of the American Academy of Dermatology·P WolfM Duvic

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Citations

Jan 31, 2002·American Journal of Clinical Dermatology·Benedetta Brazzini, Nicola Pimpinelli
Apr 29, 2006·European Journal of Cancer Care·S LaubeJ Marsden
Nov 11, 2011·The Australasian Journal of Dermatology·Leona YipDavid Orchard
Oct 28, 2015·BioMed Research International·Michelle S GentileBharat B Mittal
May 4, 2016·American Journal of Clinical Dermatology·Iris WieserMadeleine Duvic
Feb 19, 2005·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Shimareet KumarElaine S Jaffe
Sep 9, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·S A Martinez-CabrialesN H Shear
Feb 27, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gunnar WagnerMichael Max Sachse
Mar 5, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gunnar WagnerMichael Max Sachse

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