PMID: 8604811Apr 1, 1996Paper

Lymphomatous polyposis. A neoplasm of either follicular mantle or germinal center cell origin

The American Journal of Surgical Pathology
M J MoynihanD D Weisenburger

Abstract

Lymphomatous polyposis (LP) is generally thought to be an expression of non-Hodgkin's lymphoma (NHL) of follicular mantle cell (MC) origin. We report nine patients with LP from more than 3,500 cases of NHL studied by the Nebraska Lymphoma Study Group. Our patients differed from those reported previously in that LP represented a follicular center cell (FCC) NHL in two of the nine cases, with the remainder consisting of MC NHL. Three patients developed LP during a relapse of previously diagnosed and treated extraintestinal MC NHL (parotid gland, tonsil, and inguinal lymph node, respectively), whereas the other six patients presented with primary LP. In seven of the nine LP cases, a large mass predominated among a myriad of small polyps. The FCC cases were confined to the small intestine, whereas the MC cases were either pan-intestinal or colonic on their localization. Two MC cases studied by Southern blotting exhibited rearrangement of the bcl-1 locus. Bcl-2 rearrangement was not detected in any of the nine cases when studied by either a polymerase chain reaction-based assay (seven cases) or by Southern blotting (two cases). To date, four patients (three MC, one FCC) have experienced recurrent NHL in gastrointestinal sites. With ...Continue Reading

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Citations

Jul 1, 1997·Journal of Clinical Gastroenterology·K HondaM Shimizu
May 11, 2002·Leukemia & Lymphoma·Yuko HashimotoMasafumi Abe
Jan 31, 2002·World Journal of Gastroenterology : WJG·Qin ZhouZou-Xung Zhen
Mar 1, 2015·Abdominal Imaging·Akshay D BahetiNikhil H Ramaiya
Feb 28, 2004·Histopathology·J R GoodladUNKNOWN Scotland and Newcastle Lymphoma Group
Feb 26, 2009·Digestive Diseases and Sciences·Takayuki MatsumotoMitsuo Iida
Jan 20, 2010·Journal of Gastroenterology·Shuji YamamotoTsutomu Chiba
Aug 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·K KanehiraG Y Lauwers
Oct 6, 2011·Archives of Pathology & Laboratory Medicine·Jerome S Burke

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