Lymphonodular hyperplasia of the terminal ileum associated with colitis shows an increase gammadelta+ t-cell density in children

The American Journal of Gastroenterology
Jorma KokkonenM Mäki

Abstract

Recently we reported a close association between lymphonodular hyperplasia (LNH) of the bulb of the duodenum and increased densities of intraepithelial gammadelta+ T-cells in subjects with untreated food allergies. In this study we sought to determine whether children with LNH of the terminal ileum (TI) show a similar correlation. The mucosal specimens taken by colonoscopy from the TIs of 22 children with LNH of the TI without colitis, 13 with right-sided colitis or pancolitis, nine with left-sided colitis, eight with Crohn's disease, and three endoscopically healthy subjects were studied for T-cell subsets with monoclonal antibodies using a three-layer peroxidase staining method. LNH of the TI was found in 32 of the 55 subjects (58%). In 22 it was the only endoscopic finding, but in nine of 13 subjects (69%) it was related to right-sided colitis or pancolitis. In patients with left-sided colitis or Crohn's disease it was diagnosed only rarely. In the whole study population, LNH of the of the TI showed a significant association with the increment in the density of gammadelta+ T-cells. The subjects with LNH of the TI and colitis starting from the cecum showed the highest values, discriminating them statistically from any other s...Continue Reading

References

Jan 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Schou
Aug 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·T RuuskaJ K Visakorpi
Aug 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·T RuuskaM Mäki
Jul 3, 1998·Gastroenterology·C Fiocchi
Jul 10, 1999·Journal of Pediatric Gastroenterology and Nutrition·J KokkonenA Niinimäki

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Citations

Oct 16, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jani RytkönenJorma Kokkonen
Aug 9, 2003·The American Journal of Gastroenterology·Magee L DeFeliceKurt A Brown
Mar 21, 2012·Alimentary Pharmacology & Therapeutics·P MansuetoA Carroccio

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