PMID: 8597362Dec 29, 1995Paper

Lymphopoiesis, apoptosis, and immune amnesia

Annals of the New York Academy of Sciences
A D DonnenbergV S Donnenberg

Abstract

Bone marrow transplant recipients have a functional T-cell deficit long after T-cell counts have returned to normal levels. Early after BMT, T-cell phenotype is predominantly CD45RO+/CD29high/HLA-DR+/CD38high. This profile is associated with activated memory cells in healthy subjects, but also appears on the earliest mature naive T-cells in times of lymphopoietic stress. Most of these cells apoptose in short-term unstimulated culture, suggesting that they would have had a similar fate in vivo. Twelve to 24 months after BMT, CD45RA+/CD29low/HLA-DR-/CD38low T cells increase, apoptosis decreases, and T-cell function normalizes. We hypothesize that in the adult, mature memory T cells regulate their own replacement by rescuing a proportion of newly generated naive cells from apoptosis. Ablation of memory cells consequent to high dose therapy disrupts this process, resulting in a protracted period of high lymphocyte turnover with few cells surviving to make the antigen-driven transition to memory cells. Infection with HIV-1 also eventuates in immune deficiency associated with a loss in CD4+ T cells and dominance of the phenotypic/apoptotic profile which we have associated with lymphopoietic stress. Recent data independently confirm t...Continue Reading

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Citations

Aug 27, 1999·Immunology Today·L Beltz
Jan 4, 2001·International Journal of Immunopharmacology·J E TalmadgeS Buyukberber
Jul 16, 2003·International Immunopharmacology·James E Talmadge
Nov 17, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Rosangela C VillarDewton M Vasconcelos
Sep 25, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S J ChavanS G Pahwa

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