PMID: 8381174Jan 1, 1993Paper

Lymphoproliferative disease in SCID mice reconstituted with human Sjögren's syndrome lymphocytes

Journal of Clinical Laboratory Analysis
R FoxH I Kang

Abstract

Patients with Sjögren's syndrome (SS) have increased frequency of non-Hodgkin's B-cell lymphoma. These lymphomas frequently use a specific subclass of kappa light chain (encoded by variable region gene segment Hum KV325) and exhibit bcl-2 protooncogene translocation t(14;18). In order to determine whether expansion of this B-cell subset could be reproduced in an animal model, immunodeficient SCID (CB-17) mice were reconstituted with lymphocytes from 4 different SS patients at high risk of the development of lymphoma. Tumor-like nodules developed in all 11 SCID mice that received at least 5 x 10(5) lymphocytes from SS salivary glands or peripheral blood samples. However, the tumor-like nodules in the SCID mice differed from SS lymphomas in vivo in that they (1) exhibited multiple immunoglobulin gene rearrangements; (2) did not have expansion of B-cells expressing the Hum KV325 K-light chain; and (3) lacked detectable t(14;18) translocations. Characterization of the SCID tumor-like nodules revealed a high level of Epstein-Barr virus (EBV) DNA, EBV-associated antigens (EA-R, EBNA-2, AND LMP), and the EBV-encoded cytokine BCRF-1 that is structurally similar to IL-10. These results demonstrate that the lymphoproliferation occurring ...Continue Reading

References

Dec 1, 1979·Lancet·D G MorganJ M Dowaliby
Dec 1, 1978·Annals of Internal Medicine·S S KassanT M Chused
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G Klein
Jan 1, 1991·Springer Seminars in Immunopathology·R I FoxP Pisa
Jan 1, 1990·Current Topics in Microbiology and Immunology·M G Masucci
Sep 28, 1989·The New England Journal of Medicine·R A MillerR Levy
Jan 1, 1989·Journal of Cellular Biochemistry·D A RappoleeZ Werb
Aug 1, 1989·Journal of Autoimmunity·R I FoxC S Le
Dec 1, 1989·Arthritis and Rheumatism·W K Bernreuter
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A NeriR Dalla-Favera
Nov 15, 1988·International Journal of Cancer. Journal International Du Cancer·J DillnerA Rosén
May 1, 1985·Transplantation·D W HantoR L Simmons
Jul 1, 1986·The Journal of Experimental Medicine·M L ClearyJ Sklar
Apr 30, 1987·The New England Journal of Medicine·A FishlederH Levine
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M CrescenziS J Korsmeyer
Sep 23, 1988·Science·G D Yancopoulos, F W Alt
Apr 7, 1988·Nature·R HiguchiH A Erlich
Jul 1, 1983·The Journal of Clinical Investigation·R I FoxF V Howell
Jun 1, 1980·The American Journal of Medicine·S SugaiT Nishikawa
Aug 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T Barka
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·U SchmidK Lennert
Apr 1, 1964·The American Journal of Medicine·N TALAL, J J BUNIM

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