Lymphoproliferative disorders in chronic hepatitis C

Journal of Viral Hepatitis
R IdilmanD H Van Thiel

Abstract

Chronic hepatitis C virus (HCV) infection is associated with the development of lymphoproliferative disorders (LPDs). The aim of this investigation was to determine the prevalence and characterization of monoclonal gammopathy and benign and malignant LPDs in individuals with chronic hepatitis C. A total of 233 subjects diagnosed with chronic hepatitis C (male/female ratio: 131/102, median age; 49 years) were studied. Serum and urine were examined for the presence of a monoclonal gammopathy. A bone marrow aspirate and biopsy was obtained in individuals with a monoclonal gammopathy. Thirty-two patients (13.7%, 32 of 233) had a monoclonal gammopathy; 75% of them were benign and were not associated with malignant disorders (24 of 32) while 25% were associated with malignant LPDs or a plasma cell disorder (eight of 32). Two additional subjects without monoclonal gammopathy were diagnosed as having a malignant LPDs. The prevalence of malignant LPDs/plasma cell disorder in individuals with HCV-induced chronic liver disease was 4.3%. No difference was found in terms of disease duration, HCV genotype, viral load, alanine aminotransferase level or histopathologic score between the subjects with or without a monoclonal gammopathy. The pre...Continue Reading

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Citations

Aug 13, 2005·Proceedings. Biological Sciences·Alison P Galvani
Jan 11, 2013·Hepatitis Research and Treatment·Samar Samir YoussefMervat M Mattar
Sep 19, 2012·Clinical & Developmental Immunology·Takashi Himoto, Tsutomu Masaki
Aug 2, 2012·Clinical & Developmental Immunology·Anna Linda ZignegoLaura Gragnani
Aug 14, 2009·British Journal of Haematology·Jenny BirdUNKNOWN Haemato-oncology Task Force of the British Committee for Standards in Haematology, UK Myeloma Forum and Nordic Myeloma Study
Nov 22, 2012·Journal of Medical Virology·Maryam FarahaniHossein Keyvani
Jan 10, 2017·Nature Communications·Chia-Lin ChenKeigo Machida
Oct 4, 2016·Experimental Biology and Medicine·Charles B NguyenNaushad Ali
Dec 5, 2014·World Journal of Gastroenterology : WJG·Tawfik KhouryMeir Mizrahi

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