PMID: 6166580Jan 15, 1981Paper

Lymphotoxin: an anticarcinogenic lymphokine as measured by inhibition of chemical carcinogen or ultraviolet-irradiation-induced transformation of Syrian hamster cells

International Journal of Cancer. Journal International Du Cancer
C H Evans, J A DiPaolo

Abstract

Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinogen treatment varies directly with lymphotoxin concentration. The frequency of transformation does not change following re-feeding with lymphotoxin-free medium and incubation for 6 additional days. Furthermore, transformation by ultraviolet is prevented when cells are pulsed with lymphotoxin for as few as 6 hours after irradiation. Thus, lymphotoxin has the potential to irreversibly inhibit the first recognizable morphologic step of carcinogenesis.

References

Jan 1, 1979·Annals of the New York Academy of Sciences·B W PapermasterH Friedman
Dec 1, 1979·Immunopharmacology·J O Rundell, C H Evans
Oct 1, 1977·Journal of the National Cancer Institute·R T Prehn
Aug 1, 1979·International Journal of Cancer. Journal International Du Cancer·D Brouty-BoyéC Baldwin
Feb 1, 1981·Immunopharmacology·J O Rundell, C H Evans

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Citations

Jan 1, 1990·The Journal of Clinical Investigation·M AkashiH P Koeffler
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E KovacsK Hostanska
Jul 15, 1983·International Journal of Cancer. Journal International Du Cancer·J H RansomC H Evans
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·J H Ransom, C H Evans
Jan 1, 1985·Journal of Cellular Biochemistry·G E NedwinP W Gray
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·J A DiPaoloJ Doniger
Sep 1, 1994·Annals of Surgical Oncology·D BlumbergM F Brennan

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