PMID: 6979521Apr 15, 1982Paper

Lymphotoxin enhances the susceptibility of neoplastic and preneoplastic cells to natural killer cell mediated destruction

International Journal of Cancer. Journal International Du Cancer
J H Ransom, C H Evans

Abstract

Treatment of neoplastic guinea-pig cells for 1-14 days with 300 units of guinea-pig lymphotoxin/ml medium enhanced 2- to 5-fold their susceptibility to natural killer (NK) cell-mediated cytotoxicity as measured by 4 h 51Cr and 72 h [3H]-thymidine-release assays. The NK susceptibility of human neoplastic and guinea-pig non-neoplastic cells refractory to guinea-pig lymphotoxin growth-inhibitory activity was unchanged after lymphotoxin treatment. Lymphotoxin preparations were free of detectable interferon and the enhancing activity copurified with lymphotoxin during diafiltration and isoelectric focusing. Treatment of NK cells with lymphotoxin preparations also augmented NK-mediated lysis but that activity did not copurify with lymphotoxin. As with neoplastic cells, lymphotoxin-sensitive preneoplastic cells previously treated with ultraviolet light, a chemical carcinogen, or carcinogen and the tumor-promoting agent tetradecanoylphorbol-acetate also exhibited lymphotoxin enhancement to NK-cell destruction. Thus, the immunologic hormone lymphotoxin enhances the susceptibility of lymphotoxin-sensitive cells to NK-cell destruction, indicating that these two natural immune mediators, lymphotoxin and NK cells, have the potential in conc...Continue Reading

References

Dec 1, 1979·Immunopharmacology·J O Rundell, C H Evans
May 15, 1980·International Journal of Cancer. Journal International Du Cancer·M MooreM R Potter
Feb 1, 1981·Immunopharmacology·J O Rundell, C H Evans
May 28, 1981·Nature·C S HenneyS Gillis
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·O StutmanE C Lattime
May 1, 1981·Cellular Immunology·W RosenauR Anderson
Sep 1, 1981·Cellular Immunology·C H Evans
Jan 15, 1981·International Journal of Cancer. Journal International Du Cancer·L A Kunkel, R M Welsh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.