Lymphovascular invasion in prostate cancer: prognostic significance in patients treated with radiotherapy after radical prostatectomy

Cancer
Joseph P BrooksMatthew M Poggi

Abstract

Lymphovascular invasion (LVI) is found in approximately 5% to 53% of specimens after radical prostatectomy (RP). Although LVI is associated with higher rates of recurrence after RP, its prognostic significance after postprostatectomy radiotherapy (P-XRT) is unclear. The medical records of men who received P-XRT from 1991 to 2001 at 2 institutions were reviewed for the presence of LVI in RP specimens. Multiple patient variables were evaluated for their association with LVI using Fisher exact tests and Wilcoxon rank-sum tests. The time to biochemical recurrence (BCR) and the time to distant metastases (DM) after RP were analyzed using Kaplan-Meier estimations, log-rank tests, and Cox regression analyses. Eighteen of 160 patients (11%) who received P-XRT had LVI in their RP specimen. High Gleason score and seminal vesicle invasion were associated significantly with LVI. After a median follow-up of 8.3 years after RP, 16 patients with LVI had BCR after P-XRT, 9 of whom developed DM. The median time to BCR in patients with LVI was 2.6 years (95% confidence interval [95% CI], 1.8-5.4) compared with 7.8 years (95% CI, 6.8-10.3) in patients without LVI (P < .001). Multivariate analysis revealed an adjusted relative risk for LVI of 5.5 ...Continue Reading

References

Nov 1, 1996·The American Journal of Surgical Pathology·J E McNeal, C E Yemoto
Jun 8, 2000·The American Journal of Surgical Pathology·C M HermanT M Wheeler
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew S KatzSteven A Leibel
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M RoachUNKNOWN Radiation Therapy Oncology Group 9413
Mar 18, 2004·JAMA : the Journal of the American Medical Association·Andrew J StephensonKevin M Slawin
Nov 11, 2005·The Journal of Urology·Joseph P BrooksMatthew M Poggi

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Citations

Mar 5, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jonathan TangSylvain V Costes
Nov 15, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Kailash NarayanSrinivas Kondalsamy-Chennakesavan
Aug 15, 2006·Current Opinion in Urology·Ferran Algaba
Oct 19, 2014·Diagnostic Pathology·Rodolfo MontironiLiang Cheng
Jul 16, 2008·Oral Oncology·H B JonesB Musgrove
Mar 13, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S Adamis, I M Varkarakis
Aug 15, 2006·Current Opinion in Urology

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