Lymphovascular Invasion Increases the Risk of Nodal and Distant Recurrence in Node-Negative Stage I-IIA Non-Small-Cell Lung Cancer

Oncology
Soo Yoon SungYeon-Sil Kim

Abstract

Despite complete surgical resection, 30-40% of patients with stage I-IIA non-small-cell lung cancer (NSCLC) have recurrences. We aimed to elucidate the effect of lymphovascular invasion (LVI) on the prognosis and patterns of recurrence in patients with pathologically confirmed T1-2N0 NSCLC. We evaluated 381 patients who underwent complete resection and were diagnosed with pathologic T1-2N0 NSCLC between March 2000 and January 2012. Local recurrence, nodal recurrence, and distant metastasis were defined and analyzed. LVI was present in 72 patients (18.9%). The 5-year disease-free survival (DFS) for all patients was 69.9%. Patients with LVI showed a significant decrease in 5-year DFS (47.3 vs. 74.4%, p < 0.001). LVI was a significant prognostic predictor in multivariate analysis (p = 0.003). The patients with LVI showed a significantly increased 5-year cumulative incidence of nodal recurrence (22.5 vs. 8.7%, p < 0.001) and distant metastasis (30.4 vs. 14.9%, p = 0.004). However, no difference was shown between the two groups in the 5-year cumulative incidence of local recurrence (p = 0.416). LVI is a negative prognostic factor in patients with stage I-IIA NSCLC. The presence of LVI significantly increases the risk of nodal and di...Continue Reading

References

Jan 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·N MartiniR J Ginsberg
Oct 23, 1997·Chest·T NarukeH Nakayama
Mar 14, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomoshi TsuchiyaNaoya Yamasaki
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine M W PistersUNKNOWN American Society of Clinical Oncology
Oct 2, 2009·Archives of Pathology & Laboratory Medicine·Mary Kay WashingtonUNKNOWN Members of the Cancer Committee, College of American Pathologists
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jun 17, 2010·The American Journal of Surgical Pathology·Gabriel SicaAndre L Moreira
May 24, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kristin A HigginsChris R Kelsey
Jun 15, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Naoki YanagawaGen Tamura
Aug 6, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K M Monirul IslamApar Kishor Ganti
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M StahlUNKNOWN ESMO Guidelines Working Group
Jan 15, 2014·World Journal of Surgical Oncology·Ying-Yi ChenShih-Chun Lee
Mar 4, 2014·Asian Cardiovascular & Thoracic Annals·Bassel S Al-AlaoKenneth J O'Byrne
Feb 2, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ulas SolmazEmel Ebru Pala
Mar 26, 2015·Translational Lung Cancer Research·Hidetaka Uramoto, Fumihiro Tanaka
Jul 15, 2015·Radiation Oncology Journal·In-Hye JungEun Kyung Choi
Apr 17, 2016·The Journal of Contemporary Dental Practice·Tina Elizabeth JacobShankargouda Patil
Mar 11, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyu-Won JungUNKNOWN Community of Population-Based Regional Cancer Registries
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Oct 8, 2020·Journal of Gastric Cancer·Byunghyuk YuHo Young Chung
Jun 20, 2020·European Journal of Radiology·Guangjie YangZhenguang Wang
Jan 28, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rowena YipUNKNOWN International Early Lung Cancer Action Program Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.