Lymphovascular space invasion as a predictive factor for lymph node metastases and survival in endometrioid endometrial cancer - a Swedish Gynecologic Cancer Group (SweGCG) study

Acta Oncologica
Karin StålbergThomas Högberg

Abstract

Background: The aim of this study is to evaluate the impact of lymphovascular space invasion (LVSI) on the risk of lymph node metastases and survival in endometrioid endometrial adenocarcinoma.Material and methods: As regard the study design, this is a cohort study based on prospectively recorded data. Patients with endometrioid endometrial adenocarcinoma registered in the Swedish Quality Registry for Gynecologic Cancer 2010-2017 with FIGO stages I-III and verified nodal status were identified (n = 1587). LVSI together with established risk factors, namely DNA ploidy, FIGO grade, myometrial invasion and age, were included in multivariable regression analyses with lymph node metastases as the dependent variable. Associations between the risk factors and overall and relative survival were included in multivariable models. Estimates of risk ratios (RR), hazard ratios (HR), excess mortality rate ratios (EMR), and 95% confidence intervals (95% CI) were calculated.Results: The presence of LVSI presented the strongest association with lymph node metastases (RR = 5.46, CI 3.69-8.07, p < .001) followed by deep myometrial invasion (RR = 1.64, CI 1.13-2.37). In the multivariable survival analyses, LVSI (EMR = 7.69, CI 2.03-29.10,) and non...Continue Reading

References

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Citations

Oct 22, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anne Sophie V M van den HeerikCarien L Creutzberg
Dec 31, 2020·International Journal of Molecular Sciences·Ivana FridrichovaKarol Kajo
Mar 16, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Björg JónsdóttirThomas Högberg
Aug 8, 2021·Hormone Molecular Biology and Clinical Investigation·Mohamad Nasir ShafieeReena Rahayu Md Zain
Jul 10, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Åsa ÅkessonPernilla Dahm-Kähler

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