PMID: 7513431Apr 26, 1994Paper

Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells

Proceedings of the National Academy of Sciences of the United States of America
R H ScheuermannJ W Uhr

Abstract

Signal transduction initiated by binding of antibodies to cell surface molecules can have an important impact on the growth of tumor cells. The malignant behavior of the murine lymphoma BCL1 can be suppressed and the neoplastic cells can be induced to enter a dormant state by in vivo ligation of membrane immunoglobulin. Anti-CD19 antibodies can prolong the survival of SCID mice challenged with the human Burkitt lymphoma cell line, Daudi. Here, we show that cross-linking of membrane immunoglobulin on both murine BCL1 and human Daudi cells initiates a cascade of signals leading to the induction of both apoptosis and cell cycle arrest in vitro. Using antisense oligonucleotides, we demonstrate that the immunoglobulin-associated Lyn tyrosine kinase is required for anti-immunoglobulin-mediated cell cycle arrest but is not required for the signal leading to apoptosis. These results define a branch point in the cytosolic signaling pathways mediating cell cycle arrest and apoptosis. In Daudi cells, Lyn is also critical for cell cycle arrest induced by anti-CD19 signaling. Thus, the Lyn tyrosine kinase may be an important mediator of cell cycle arrest in neoplastic B lymphocytes and, perhaps, other cell types.

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Citations

Feb 5, 2005·Cancer Immunology, Immunotherapy : CII·Michela Cesco-GaspereOscar R Burrone
Dec 2, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gerald J Mizejewski
Jan 12, 1996·Biochimica Et Biophysica Acta·G P BorissevitchO N Oliveira
Aug 1, 1997·Molecular Immunology·S MuthukkumarS Bondada
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·T FukudaT Watanabe
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S AndersonH H Wortis
Jan 1, 1996·Fundamental & Clinical Pharmacology·L Ma, F Calvo
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·M WelschofG Opelz
Jul 8, 2008·Médecine sciences : M/S·Bruno Quesnel
Aug 1, 1995·Leukemia & Lymphoma·R H Scheuermann, E Racila
Oct 7, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Bruno Quesnel
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·M MayumiK Katamura
Sep 13, 1996·The Journal of Biological Chemistry·A C LankesterR A van Lier
Jun 29, 1999·Cellular Immunology·I Melamed, E W Gelfand

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