Lynch syndrome - cancer pathways, heterogeneity and immune escape.

The Journal of Pathology
Sidhant SethIan M Frayling

Abstract

Recent work has provided evidence for genetic and molecular heterogeneity in colorectal cancers (CRCs) arising in patients with Lynch syndrome (LS), dividing these into two groups: G1 and G2. In terms of mutation and gene expression profile, G1 CRCs bear resemblance to sporadic CRCs with microsatellite instability (MSI), whereas G2 CRCs are more similar to microsatellite-stable CRCs. Here we review the current state of knowledge on pathways of precursor progression to CRC in LS and how these might tie in with the new findings. Immunotherapies are an active field of research for MSI cancers and their potential use for cancer therapy for both sporadic and LS MSI cancers is discussed. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Citations

Mar 7, 2019·The Journal of Pathology·Ralph H HrubanLaura D Wood
Nov 5, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aurelien MarabelleLuis A Diaz
Jul 20, 2020·International Journal of Cancer. Journal International Du Cancer·Aysel AhadovaMatthias Kloor
Mar 7, 2020·The Journal of Pathology·Guia CerretelliIan M Frayling
Oct 23, 2019·Hereditary Cancer in Clinical Practice·Mev Dominguez-ValentinPål Møller
Oct 16, 2020·Molecular Genetics & Genomic Medicine·Yirong LiLiying Zhang
Apr 20, 2021·Cancer Immunology, Immunotherapy : CII·Inken SalewskiClaudia Maletzki
Jun 25, 2021·Frontiers in Oncology·Mahnaz NorouziMohammad Amin Tabatabaiefar
Sep 21, 2021·The Journal of Pathology·Guia CerretelliMark J Arends

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