Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena.

Marine Drugs
Jason C KwanHendrik Luesch

Abstract

Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8-10 (1-3). The structures of 1-3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1-3 are closely related to lyngbyastatins 4-7. Like the latter compounds, we found 1-3 to inhibit porcine pancreatic elastase, with IC(50) values of 123 nM, 210 nM and 120 nM, respectively.

References

Mar 4, 1999·Journal of Magnetic Resonance·W C Tennant, R F Claridge
Jul 27, 2002·Journal of Natural Products·Alexei PloutnoShmuel Carmeli
Oct 30, 2003·Chemistry & Biology·Ute MaternGeorg E Schulz
Feb 1, 2005·Journal of Natural Products·Hiroshi YamakiKunimitsu Kaya
Sep 27, 2005·Journal of Natural Products·Eric von ElertJudith F Blom
Jan 21, 2006·Journal of Magnetic Resonance·William W BreyRichard S Withers
Oct 4, 2007·Journal of Natural Products·Kanchan TaoriHendrik Luesch
Jan 22, 2008·Journal of the American Chemical Society·Kanchan TaoriHendrik Luesch

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Citations

Jul 16, 2010·Marine Drugs·Li Liu, Kathleen S Rein
Oct 16, 2010·Marine Drugs·Maria Teresa CabritaAmélia Pilar Rauter
May 1, 2012·TheScientificWorldJournal·Bushra UzairSaima Firdous Rehman
Oct 18, 2014·Amino Acids·Dawid Siodłak
Nov 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Apostolis AngelisJean-Hugues Renault
May 26, 2017·Journal of Natural Products·Arihiro IwasakiKiyotake Suenaga
Sep 13, 2011·Journal of Applied Toxicology : JAT·M NagarajanM Sundararaman
Mar 5, 2014·Chembiochem : a European Journal of Chemical Biology·Jason C KwanHendrik Luesch
Dec 24, 2011·Natural Product Reports·John W BluntMichèle R Prinsep
Jun 4, 2019·Marine Drugs·Justine DemayBenjamin Marie
Jun 11, 2020·Natural Product Reports·Fatma H Al-Awadhi, Hendrik Luesch
Dec 15, 2010·Natural Product Reports·John W BluntMichèle R Prinsep
Jun 26, 2020·Frontiers in Pharmacology·Shabir AhmadMahmoud Fahmi Elsebai
Jan 22, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·D-P HäderR C Worrest
May 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lik Tong Tan, Ma Yadanar Phyo
Jan 3, 2021·International Journal of Biological Macromolecules·Noora BarzkarReza Nahavandi
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hina QamarBenoît Chénais
Dec 23, 2020·International Journal of Molecular Sciences·Dimitris PappasEmmanuel Panteris
May 24, 2016·Bioorganic & Medicinal Chemistry·Fatma H Al-AwadhiHendrik Luesch
Mar 5, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Abdur RaufKannan Rr Rengasamy
Dec 22, 2009·Journal of Natural Products·Sarath P GunasekeraValerie J Paul
Nov 5, 2010·The Journal of Organic Chemistry·Jason C KwanHendrik Luesch
Jun 27, 2018·Journal of Natural Products·Yuki KanamoriKiyotake Suenaga
May 29, 2018·Journal of Natural Products·David A GallegosKerry L McPhail
Nov 9, 2021·Journal of Basic Microbiology·Aqsa ShahidMuhammad Waseem

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Methods Mentioned

BETA
NMR

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