Lynn Margulis and the endosymbiont hypothesis: 50 years later

Molecular Biology of the Cell
Michael W Gray

Abstract

The 1967 article "On the Origin of Mitosing Cells" in the Journal of Theoretical Biology by Lynn Margulis (then Lynn Sagan) is widely regarded as stimulating renewed interest in the long-dormant endosymbiont hypothesis of organelle origins. In her article, not only did Margulis champion an endosymbiotic origin of mitochondria and plastids from bacterial ancestors, but she also posited that the eukaryotic flagellum (undulipodium in her usage) and mitotic apparatus originated from an endosymbiotic, spirochete-like organism. In essence, she presented a comprehensive symbiotic view of eukaryotic cell evolution (eukaryogenesis). Not all of the ideas in her article have been accepted, for want of compelling evidence, but her vigorous promotion of the role of symbiosis in cell evolution unquestionably had a major influence on how subsequent investigators have viewed the origin and evolution of mitochondria and plastids and the eukaryotic cell per se.

References

Jan 1, 1992·International Review of Cytology·M W Gray
Jan 1, 1987·Annals of the New York Academy of Sciences·T Cavalier-Smith
Aug 18, 1972·Science·R A Raff, H R Mahler
Aug 14, 1970·Science·P H Raven
Jan 1, 1981·Annals of the New York Academy of Sciences·H R Mahler
Jan 1, 1981·Medical Physics·L KaufmanA R Margulis
Mar 1, 1994·Journal of Molecular and Cellular Cardiology·J L Sapp, S E Howlett
Mar 24, 1998·Nature·W Martin, M Müller
Mar 5, 1999·Science·M W GrayB F Lang
Mar 1, 1967·Journal of Theoretical Biology·L Sagan
Nov 5, 2002·Trends in Genetics : TIG·John M Archibald, Patrick J Keeling
Dec 3, 2003·Trends in Genetics : TIG·Gertraud BurgerB Franz Lang
Dec 1, 1991·Trends in Cell Biology·K A Johnson, J L Rosenbaum
Sep 7, 2012·Cold Spring Harbor Perspectives in Biology·Michael W Gray
Jan 22, 2013·Genome Biology and Evolution·Gertraud BurgerB Franz Lang
Jan 30, 2013·Biochemical Society Transactions·Joran Martijn, Thijs J G Ettema
Jul 31, 2013·Critical Reviews in Biochemistry and Molecular Biology·V Lila KoumandouMark C Field
Jun 1, 2014·PloS One·Anita M NedosykoKaren Burke da Silva
Jul 20, 2014·Cold Spring Harbor Perspectives in Biology·Anthony M Poole, Simonetta Gribaldo
Sep 2, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·William F MartinVerena Zimorski
Feb 4, 2016·Nature·Alexandros A Pittis, Toni Gabaldón
May 18, 2016·Current Biology : CB·Anna KarnkowskaVladimír Hampl
Jan 13, 2017·Nature·Katarzyna Zaremba-NiedzwiedzkaThijs J G Ettema

❮ Previous
Next ❯

Citations

Nov 11, 2017·Frontiers in Neuroscience·Serge Nataf
Dec 8, 2017·Frontiers in Molecular Biosciences·Matthew J Young
Oct 26, 2018·IUBMB Life·Michael W Gray, Vamsi K Mootha
Mar 23, 2019·Annals of the New York Academy of Sciences·James A Shapiro
Aug 9, 2017·Journal of Molecular Evolution·Kathryn A LanierLoren Dean Williams
Nov 21, 2018·Journal of Molecular Evolution·Calvin M RunnelsLoren Dean Williams
Jun 19, 2019·International Journal of Molecular Sciences·Youri Timsit, Daniel Bennequin
May 14, 2020·F1000Research·Rafael Zardoya
Aug 24, 2017·The Journal of Biological Chemistry·Thomas D NiehausAndrew D Hanson
Nov 21, 2018·Microbial Ecology in Health and Disease·Alison M MooreJørgen Valeur
Dec 16, 2017·Genesis : the Journal of Genetics and Development·Anthony P BarrassoRoss A Poché
Apr 25, 2020·Frontiers in Physiology·Devasena Ponnalagu, Harpreet Singh
Aug 30, 2020·International Journal of Molecular Sciences·Jakub MieleckiStanisław Karpiński
Feb 8, 2021·Bio Systems·František Baluška, Sherrie Lyons
Dec 4, 2020·Nature Communications·Alessandro L V CoradiniIan M Ehrenreich
Jun 14, 2020·Mitochondrion·Marco ZancaniGiovanna Lippe
Apr 4, 2021·International Journal of Molecular Sciences·Sonia Romero-CorderoConstanza Morén
Jul 30, 2017·Journal of Theoretical Biology·Ajith Harish, Charles G Kurland
May 2, 2021·Biochimica Et Biophysica Acta. Bioenergetics·Olga FedotovskayaPia Ädelroth
May 14, 2021·Nature·Javier Garcia-Bermudez, Kıvanç Birsoy
Jun 3, 2021·Microorganisms·Dongmei LyuDonald L Smith
Jun 26, 2021·Ageing Research Reviews·Mario F Munoz-PintoSandra M Cardoso
Jul 3, 2021·International Journal of Molecular Sciences·Javier RamónRamon Martí
Aug 21, 2021·Critical Care Medicine·Shingo YasuharaJ A Jeevendra Martyn
Aug 27, 2021·The FEBS Journal·Seyta Ley-Ngardigal, Giulia Bertolin
Aug 4, 2021·Annual Review of Microbiology·Toni Gabaldón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
H Ishikawa
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Michael W Gray
© 2022 Meta ULC. All rights reserved