Lyonization in ophthalmology

Current Opinion in Ophthalmology
Wadakarn WuthisiriAlex V Levin

Abstract

To describe the entity of Lyonization in ocular eye diseases, along with its clinical and counseling implications. Several X-linked ocular diseases such as choroideremia, X-linked retinitis pigmentosa, and X-linked ocular albinism may have signs of Lyonization on ocular examination and diagnostic testing. These findings may aid in the proper diagnosis of ocular disease in both female carriers and their affected male relatives. Manifestations of Lyonization in the eye may help in the diagnosis of X-linked ocular diseases which may lead to accurate diagnosis, appropriate molecular genetic testing and genetic counseling.

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Citations

Jul 16, 2014·Current Eye Research·Saradha Iragavarapu, Michael B Gorin
Oct 19, 2017·Retinal Cases & Brief Reports·Jesse D SengilloStephen H Tsang
May 18, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Katherine J WertVinit B Mahajan
Feb 25, 2017·Retina·Kamron N KhanMichel Michaelides
Aug 31, 2018·American Journal of Medical Genetics. Part a·Bjørn K Fabian-JessingMichael B Petersen
Aug 8, 2015·Expert Opinion on Orphan Drugs·Ioannis S DimopoulosIan M MacDonald

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