Lyophilization of Liposomal Formulations: Still Necessary, Still Challenging

Pharmaceutics
Silvia FranzéFrancesco Cilurzo

Abstract

Nowadays, the freeze-drying of liposome dispersions is still necessary to provide a solid dosage form intended for different routes of administration (i.e., parenteral, oral, nasal and/or pulmonary). However, after decades of studies the optimization of process conditions remains still challenging since the freezing and the dehydration destabilize the vesicle organization with the concomitant drug leakage. Starting from the thermal properties of phospholipids, this work reviews the main formulation and process parameters which can guarantee a product with suitable characteristics and increase the efficiency of the manufacturing process. In particular, an overview of the cryo- and/or lyo-protective mechanisms of several excipients and the possible use of co-solvent mixtures is provided. Attention is also focused on the imaging methods recently proposed to characterize the appearance of freeze-dried products and liposome dispersions upon reconstitution. The combination of such data would allow a better knowledge of the factors causing inter-vials variability in the attempt to improve the quality of the final medicinal product.

References

May 7, 1991·Biochimica Et Biophysica Acta·L M Crowe, J H Crowe
Dec 1, 1993·Chemical & Pharmaceutical Bulletin·K YasuiY Nakamura
Nov 1, 1993·Biophysical Journal·V L Bronshteyn, P L Steponkus
Jan 31, 1996·Biochimica Et Biophysica Acta·T SuzukiK Miyajima
Jan 1, 1997·Chemical & Pharmaceutical Bulletin·K Ozaki, M Hayashi
Oct 7, 1997·Biochimica Et Biophysica Acta·H NagaseM Nakagaki
Jul 17, 1998·Biochimica Et Biophysica Acta·R Koynova, M Caffrey
Feb 18, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·E C van Winden, D J Crommelin
Apr 5, 2001·Biochimica Et Biophysica Acta·K A RiskeM T Lamy-Freund
Feb 19, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dirk L Teagarden, David S Baker
Apr 30, 2003·Biophysical Journal·Andrey FilippovGöran Lindblom
May 6, 2003·Biochimica Et Biophysica Acta·Dan PeerRimona Margalit
Nov 13, 2003·Methods in Enzymology·Ewoud C van Winden
Mar 9, 2004·Biochimica Et Biophysica Acta·Willem F WolkersJohn H Crowe
Mar 23, 2004·Pharmaceutical Research·Xiaolin Tang, Michael J Pikal
Mar 26, 2004·Biophysical Journal·Cristina S PereiraPhilippe H Hünenberger
Apr 7, 2004·Journal of Pharmaceutical Sciences·D Q WangS L Nail
Feb 3, 2005·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Mar 15, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·W L J HinrichsH W Frijlink
Feb 7, 2006·International Journal of Pharmaceutics·JingXia CuiWei Wang
Feb 24, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·B CabaneC Neves
Mar 28, 2006·Biochimica Et Biophysica Acta·Ting WangZhixuan Wang
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J H CroweL M Crowe
Sep 26, 2006·Methods : a Companion to Methods in Enzymology·Afzal R MohammedYvonne Perrie
Nov 3, 2006·Journal of Pharmaceutical Sciences·Heidi M Mansour, George Zografi
Feb 24, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Afzal R MohammedYvonne Perrie
Feb 25, 2009·Expert Opinion on Drug Delivery·Ambikanandan MisraMahavir Chougule
Oct 31, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chengjun ChenXing Tang
Nov 7, 2009·Journal of Pharmaceutical Sciences·Per WessmanDenny Mahlin
Jan 26, 2010·Cryobiology·Véronique VincourtGilles Dumortier
Aug 31, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Brigitte StarkRuth Prassl

❮ Previous
Next ❯

Citations

Jul 24, 2020·Nanomedicine·Maria ManconiAnna Maria Fadda
Jul 11, 2020·Journal of Liposome Research·Usha SundralingamUma D Palanisamy
Jan 11, 2020·Frontiers in Bioengineering and Biotechnology·Diana GuimarãesEugénia Nogueira
Apr 17, 2020·Pharmaceutics·Rosario Pignatello, Pietro Matricardi
Feb 5, 2021·Chonnam Medical Journal·Eun-Mi Kim, Hwan-Jeong Jeong
Oct 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jafrin Jobayer SonjuSeetharama D Jois
Mar 30, 2021·International Journal of Pharmaceutics·Lirui JiaYongjun Wang
May 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Apratim JashSyed S H Rizvi
Jul 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Arto MerivaaraMarjo Yliperttula
Jul 24, 2020·Bioconjugate Chemistry·Martine DarwishCraig Blanchette
Sep 8, 2021·Biomedical Materials·Tasmia TasnimHuanan Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
environmental stress
fluorescence spectroscopy
X-ray
imaging
scanning electron microscopy
dynamic light scattering
small
angle neutron scattering
imaging techniques

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Chengjun ChenXing Tang
Journal of Controlled Release : Official Journal of the Controlled Release Society
Pedro FonteBruno Sarmento
© 2022 Meta ULC. All rights reserved