Lyophilized carrot ingestion lowers lipemia and beneficially affects cholesterol metabolism in cholesterol-fed C57BL/6J mice

European Journal of Nutrition
Catherine NicolleC Rémésy

Abstract

Several lines of evidence indicate that diet rich in fruit and vegetable can protect against cardiovascular diseases by acting on cholesterol metabolism and on oxidative stress. The aim of this study was to assess whether daily carrot consumption (provided as lyophilized powder) could differentially influence the consequences of cholesterol supplementation on lipid metabolism and oxidative stress in C57BL/6J mice. Fourteen mice were randomized in four groups. Mice were fed either control diets (without or with 0.25% cholesterol added) or lyophilized carrot enriched diets (20% wt/wt without or with 0.25 % cholesterol added) for 4 weeks. Cholesterol and triglycerides in plasma and in liver were measured at the end of the experimental period. Fecal excretion of sterols was evaluated. Vitamin E and carotenoid concentrations were also determined. Several biomarkers relative to oxidative stress such as FRAP (Ferric Reducing Ability of Plasma) and isoprostanes were investigated. Feeding the carrot diet resulted in a decrease of cholesterol (-41%) and triglycerides (-49 %) in plasma and in the liver (-41% and -39%, respectively) in animals fed cholesterol-supplemented diets. Carrot diet induced an increase of total neutral sterols feca...Continue Reading

Citations

Jan 31, 2014·Journal of Medicinal Food·Shahrzad ForoudiFarzad Deyhim
Oct 16, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hanna LeontowiczShela Gorinstein
Jun 15, 2006·The Journal of Nutrition·Michael R AdamsEric T Gugger
Jul 16, 2016·Journal of the Science of Food and Agriculture·Malleswarapu MaheshShanmugam M Jeyakumar
Oct 24, 2014·Journal of Agricultural and Food Chemistry·Chuan LiMing-Yong Xie

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