Lyotropic liquid crystal preconcentrates for the treatment of periodontal disease

International Journal of Pharmaceutics
A FehérE Csányi

Abstract

The aim of our study was to develop water-free lyotropic liquid crystalline preconcentrates, which consist of oils and surfactants with good physiological tolerance and spontaneously form lyotropic liquid crystalline phase in aqueous environment. In this way these preconcentrates having low viscosity can be injected into the periodontal pocket, where they are transformed into highly viscous liquid crystalline phase, so that the preparation is prevented from flowing out of the pocket due to its great viscosity, while drug release is controlled by the liquid crystalline texture. In order to follow the structure alteration upon water absorption polarization microscopical and rheological examinations were performed. The water absorption mechanism of the samples was examined by the Enslin-method. Metronidazole-benzoate was used as active agent the release of which was characterized via in vitro investigations performed by means of modified Kirby-Bauer disk diffusion method. On the grounds of the results it can be stated that the 4:1 mixture of the investigated surfactants (Cremophor EL, Cremophor RH40) and oil (Miglyol 810) formed lyotopic liquid crystalline phases upon water addition. Polarization microscopic examinations showed th...Continue Reading

References

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Citations

Feb 2, 2013·International Journal of Pharmaceutical Investigation·Mohammad TariqJasjeet K Sahni
Jun 28, 2011·Colloids and Surfaces. B, Biointerfaces·Jessica PhelpsLuciana B Lopes
Jan 30, 2013·Pharmaceutical Development and Technology·Sabrina Barbosa de Souza FerreiraMarcos Luciano Bruschi
Dec 6, 2014·International Journal of Pharmaceutics·Spomenka Milak, Andreas Zimmer
Mar 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juliana F de SouzaMarco V Chaud
Dec 16, 2016·Nanoscale·Alexandru ZabaraCalum J Drummond
Jan 29, 2014·Chemical Communications : Chem Comm·Alexandru ZabaraRaffaele Mezzenga
Feb 24, 2021·AAPS PharmSciTech·Xingwang Zhang, Wei Wu
Apr 22, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Alexandru ZabaraRaffaele Mezzenga
Sep 15, 2009·Colloids and Surfaces. B, Biointerfaces·Tehila MishrakiNissim Garti

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