Lysine acetylation and the bromodomain: a new partnership for signaling

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Xiang-Jiao Yang

Abstract

Lysine acetylation has been shown to occur in many protein targets, including core histones, about 40 transcription factors and over 30 other proteins. This modification is reversible in vivo, with its specificity and level being largely controlled by signal-dependent association of substrates with acetyltransferases and deacetylases. Like other covalent modifications, lysine acetylation exerts its effects through "loss-of-function" and "gain-of-function" mechanisms. Among the latter, lysine acetylation generates specific docking sites for bromodomain proteins. For example, bromodomains of Gcn5, PCAF, TAF1 and CBP are able to recognize acetyllysine residues in histones, HIV Tat, p53, c-Myb or MyoD. In addition to the acetyllysine moiety, the flanking sequences also contribute to efficient recognition. The relationship between acetyllysine and bromodomains is reminiscent of the specific recognition of phosphorylated residues by phospho-specific binding modules such as SH2 domains and 14-3-3 proteins. Therefore, lysine acetylation forges a novel signaling partnership with bromodomains to govern the temporal and spatial regulation of protein functions in vivo.

References

May 25, 1992·Nucleic Acids Research·S R HaynesI B Dawid
Dec 27, 1996·Cell·B R CairnsR D Kornberg
May 1, 1997·Trends in Biochemical Sciences·F JeanmouginR Losson
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·R RamakrishnanR B Bourret
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·W Zhang, J J Bieker
Sep 23, 1998·Genes & Development·K SakaguchiE Appella
Nov 2, 1999·The EMBO Journal·R E KiernanC Van Lint
Jan 19, 2000·Nature·B D Strahl, C D Allis
Feb 9, 2000·Genomics·M H JonesM Shimane
Feb 17, 2000·The EMBO Journal·M A Martínez-BalbásT Kouzarides
Mar 16, 2000·The EMBO Journal·T Kouzarides
Feb 7, 2001·The Journal of Biological Chemistry·G MarzioM Giacca
May 10, 2000·Current Biology : CB·A J BannisterT Kouzarides
Jun 3, 2000·The EMBO Journal·H SeimiyaT Tsuruo
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·D E Sterner, S L Berger
Jul 6, 2000·Molecular Cell·E SoutoglouI Talianidis
Aug 17, 2000·The Journal of Biological Chemistry·A PolesskayaA Harel-Bellan
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B M Turner
Nov 14, 2000·The Journal of Biological Chemistry·Y Sano, S Ishii
Nov 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y XueW Wang
Nov 25, 2000·Journal of Molecular Biology·B P HudsonP E Wright
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·Q ZhangR H Goodman
Jan 23, 2001·The Journal of Biological Chemistry·H L HungG A Blobel
Mar 27, 2001·Current Biology : CB·C J Fry, C L Peterson

❮ Previous
Next ❯

Citations

Mar 1, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Niall Dillon
Apr 1, 2011·Clinical Epigenetics·Wladyslaw A Krajewski, Oleg L Vassiliev
May 25, 2010·Nature Structural & Molecular Biology·Yonathan Lissanu DeribeIvan Dikic
Jan 18, 2012·Oncogene·S MunroN B La Thangue
Feb 28, 2007·Cell Research·Paola GallinariChristian Steinkühler
Jan 11, 2007·Oncogene·I RizR G Hawley
Aug 19, 2007·Molecular BioSystems·Jocelyn E Krebs
Mar 10, 2012·Molecular BioSystems·Shao-Ping ShiRu-Ping Liang
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Chunfen ZhangMonita P Wilson
Apr 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Leslie MitchellKristin Baetz
Nov 10, 2011·The Journal of Biological Chemistry·Christian HenningMarcus A Glomb
Feb 16, 2012·The Journal of Biological Chemistry·Byeong-Gu HanByung Il Lee
Apr 16, 2009·Molecular & Cellular Proteomics : MCP·Hong LiYixue Li
Feb 12, 2008·Nucleic Acids Research·Christine BuerkiMichael O Hottiger
Mar 2, 2013·Nucleic Acids Research·Samuel T FatobaAndrei L Okorokov
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anilkumar Bettegowda, Miles F Wilkinson
Jul 5, 2006·Genes & Development·Scott J BultmanTerry Magnuson
Apr 3, 2012·Genes & Development·Kinga KamieniarzRobert Schneider
Feb 17, 2006·Genes & Development·Oliver H KrämerThorsten Heinzel
Oct 17, 2007·Genes & Development·Michael PotenteStefanie Dimmeler
Jan 28, 2009·Genes & Development·Oliver H KrämerThorsten Heinzel
Feb 12, 2011·Plant Physiology·Iris FinkemeierLee J Sweetlove
Dec 2, 2008·Pigment Cell & Melanoma Research·Hunter W Richards, Estela E Medrano
Aug 11, 2005·Science's STKE : Signal Transduction Knowledge Environment·Inna Nusinzon, Curt M Horvath
May 29, 2007·Molecular and Cellular Biology·Melissa Durant, B Franklin Pugh
Sep 24, 2008·Molecular and Cellular Biology·Jennifer K ChoiLeann J Howe
Dec 13, 2006·Molecular and Cellular Biology·Serge GrégoireXiang-Jiao Yang
Jul 11, 2007·Molecular and Cellular Biology·Debabrata BiswasDavid J Stillman
Aug 31, 2006·Molecular and Cellular Biology·Gordin ZupkovitzChristian Seiser
Dec 24, 2008·Molecular and Cellular Biology·Bo HuangLin-Feng Chen
May 18, 2006·Molecular and Cellular Biology·Béatrice EyminSylvie Gazzeri
Mar 4, 2005·Molecular and Cellular Biology·Serge Grégoire, Xiang-Jiao Yang
Mar 31, 2005·Molecular and Cellular Biology·Xiang-Jiao Yang, Serge Grégoire
Sep 9, 2005·Microbiology and Molecular Biology Reviews : MMBR·Jerry Eichler, Michael W W Adams

❮ Previous
Next ❯

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