Lysine catabolism, amino acid transport, and systemic acquired resistance: what is the link?

Plant Signaling & Behavior
Huaiyu Yang, Uwe Ludewig

Abstract

Lysine is an essential amino acid for human nutrition, which is generally low in cereal diets. Its biosynthesis via the aspartate-pathway and catabolism is controlled by complex feedback mechanisms. Recently, aspartate-derived amino acids were found to be elevated during pathogen infection in Arabidopsis and a lysine catabolite, pipecolic acid, was identified as critical regulator of systemic acquired resistance. Pipecolic acid is mobile in plants, functions as an intensifier of defense responses and mediates systemic acquired resistance establishment via signal amplification. The altered pathogen defense in several mutants with altered homeostasis of aspartate-derived amino acids, such as lysine, had already provided a genetic link with amino acid homeostasis. Furthermore, the modification of amino acid transport and distribution within tissues not only affected the plant growth performance, but also the plant-pathogen interaction. The ectopic overexpression of a gene encoding a high affinity importer with preference to basic amino acids, such as lysine, cationic amino acid transporter1 (CAT1), improved the disease resistance to a hemibiotrophic bacterial pathogen in Arabidopsis via a constitutively activated salicylic acid pa...Continue Reading

References

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Citations

Aug 13, 2014·Journal of Experimental Botany·Réjane Pratelli, Guillaume Pilot
Feb 16, 2020·Biomolecules·Ryan J Emenecker, Lucia C Strader
Jun 23, 2020·Organic & Biomolecular Chemistry·Jun TakeuchiYasushi Todoroki
Feb 18, 2017·BMC Plant Biology·Teresa Donze-ReinerGautam Sarath
Oct 11, 2017·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Zihong YeXiaoping Yu
Jan 23, 2020·International Journal of Molecular Sciences·Yuming SunShiwei Guo
Jul 15, 2017·Seminars in Cell & Developmental Biology·Kasia DinkelooGuillaume Pilot

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