PMID: 2492500Jan 1, 1989Paper

Lysine catabolism in Streptomyces spp. is primarily through cadaverine: beta-lactam producers also make alpha-aminoadipate

Journal of Bacteriology
K MadduriL C Vining

Abstract

Genetic and biochemical evidence was obtained for lysine catabolism via cadaverine and delta-aminovalerate in both the beta-lactam producer Streptomyces clavuligerus and the nonproducer Streptomyces lividans. This pathway is used when lysine is supplied as the sole source of nitrogen for the organism. A second pathway for lysine catabolism is present in S. clavuligerus but not in S. lividans. It leads to alpha-aminoadipate, a precursor for beta-lactam biosynthesis. Since it does not allow S. clavuligerus to grow on lysine as the sole nitrogen source, this pathway may be used exclusively to provide a precursor for beta-lactam biosynthesis. beta-Lactam producers were unable to grow well on alpha-aminoadipate as the only nitrogen source, whereas three of seven species not known to produce beta-lactam grew well under the same conditions. Lysine epsilon-aminotransferase, the initial enzyme in the alpha-aminoadipate pathway for lysine catabolism, was detected in cell extracts only from the beta-lactam producers. These results suggest that synthesis of alpha-aminoadipate is exclusively a secondary metabolic trait, present or expressed only in beta-lactam producers, while genes governing the catabolism of alpha-aminoadipate are present...Continue Reading

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Citations

Oct 1, 2003·Journal of Biosciences·Aarohi DharwadkarAditi Pant
Mar 19, 2013·Applied Microbiology and Biotechnology·Felicitas FaziusMatthias Brock
May 2, 1994·Annals of the New York Academy of Sciences·A L DemainJ F Martin
Jan 19, 2006·Journal of Industrial Microbiology & Biotechnology·Min He
Nov 14, 2015·FEMS Microbiology Letters·Carla Andréa LeiteMaria L G C Araujo
Jul 1, 2006·Critical Reviews in Biotechnology·Arnold L Demain, Preeti Vaishnav
Jun 1, 1991·Applied Microbiology and Biotechnology·K MadduriL C Vining
May 10, 2011·Applied Microbiology and Biotechnology·Jens Schneider, Volker F Wendisch
Jun 19, 2007·Journal of Bacteriology·Dylan C AlexanderSusan E Jensen
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·A A Brakhage
Oct 9, 2009·Journal of Proteome Research·Yulan WangElaine Holmes

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